ArticleBMC plant biology2019
The grapevine R2R3-type MYB transcription factor VdMYB1 positively regulates defense responses by activating the stilbene synthase gene 2 (VdSTS2).
Article in BMC plant biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 77 citations in OpenAlex.
- A miR858 variant negatively regulates resistance to tea leaf spot through targeting the CsMYB1-CsPME41 module.Molecular horticulture · 2026Article
- Research progress on the biosynthesis and regulatory mechanisms of resveratrol in plants.Frontiers in plant science · 2026Review
- Transient Overexpression ofPlants (Basel, Switzerland) · 2025Article
- Recent advances in improving yield and immunity through transcription factor engineering.Journal of integrative plant biology · 2025Review
- A Comparative Transcriptomic Study Reveals Temporal and Genotype-Specific Defense Responses toJournal of fungi (Basel, Switzerland) · 2025Article
- Article
- Advances in the molecular mechanism of grapevine resistance to fungal diseases.Molecular horticulture · 2025Review
- Integrative analysis of co-expression networks and codon usage bias in maize under biotic stress.PloS one · 2025Article
- Soil-Mulching Treatment Enhances the Content of Stilbene in Grape Berries: A Transcriptomic and Metabolomic Analysis.Foods (Basel, Switzerland) · 2024Article
- Fine mapping and identification of candidate genes associated with powdery mildew resistance in melon (Horticulture research · 2024Article
- A New Approach for CRISPR/Cas9 Editing and Selection of Pathogen-Resistant Plant Cells of Wine Grape cv. 'Merlot'.International journal of molecular sciences · 2024Article
- WildMolecules (Basel, Switzerland) · 2024Article
- Integrated multi-omics investigation revealed the importance of phenylpropanoid metabolism in the defense response ofHorticulture research · 2024Article
- Genome-Wide Analysis ofInternational journal of molecular sciences · 2024Article
- Molecular Mechanism of Resistance toInternational journal of molecular sciences · 2024Article
- The MYB Transcription FactorInternational journal of molecular sciences · 2024Article
- Overexpression of a 'Beta' MYB Factor Gene,International journal of molecular sciences · 2024Article
- Hybrid Fruits for Improving Health-A Comprehensive Review.Foods (Basel, Switzerland) · 2024Review
- Genome-Wide Identification and Analysis ofPlants (Basel, Switzerland) · 2023Article
- UV-B promotes flavonoid biosynthesis inHorticulture research · 2023Article
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7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundResveratrol is a naturally occurring plant stilbene that exhibits a wide range of valuable biological and pharmacological properties. Although the beneficial effects of trans-resveratrol to human health and plant protection against fungal pathogens and abiotic stresses are well-established, yet little is known about the molecular mechanisms regulating stilbene biosynthesis in plant defense progress.
resultsHere, we cloned and identified the Chinese wild grape (Vitis davidii) R2R3-MYB transcription factor VdMYB1, which activates defense responses against invading pathogen. VdMYB1 transcripts were significantly upregulated after inoculation with the grapevine powdery mildew fungus Erysiphe necator (Schw.) Burr. Transient expression analysis using onion epidermal cells and Arabidopsis thaliana protoplasts showed that VdMYB1 was localized in the nucleus. Yeast one-hybrid assays revealed that VdMYB1 acts as a transcriptional activator. Grapevine leaves transiently overexpressing VdMYB1 showed a lower number of fungal conidiophores compared with wild-type leaves. Overexpression of VdMYB1 in grapevine leaves did not alter the expression of genes in salicylic acid- and jasmonate-dependent pathways, but affected the expression of stilbene synthase (STS) genes, key regulators of flavonoid metabolism. Results of electrophoretic mobility shift assays and in vivo transcriptional activation assays showed that VdMYB1 binds to the MYB binding site (MYBBS) in the STS2 gene promoter, thus activating STS2 transcription. In heterologous expression assays using tobacco leaves, VdMYB1 activated STS2 gene expression and increased the accumulation of resveratrol.
conclusionsOur study showed that VdMYB1 activates STS2 gene expression to positively regulate defense responses, and increases the content of resveratrol in leaves.
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