ArticleMaterials (Basel, Switzerland)2019
Thermogravimetry and Mass Spectrometry of Extractable Organics from Manufactured Nanomaterials for Identification of Potential Coating Components.
Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- PDMS-Epoxy Micro-Nano Composite Structures Constructed via Open-Loop Addition Reactions and Their Optical and Antifouling Performance Modulation.Materials (Basel, Switzerland) · 2026Article
- Quantifying surface groups on aminated silica nanoparticles of different size, surface chemistry, and porosity with solution NMR, XPS, optical assays, and potentiometric titration.Nanoscale advances · 2025Article
- Highlighting the Importance of Characterization Techniques Employed in Adsorption Using Metal-Organic Frameworks for Water Treatment.Polymers · 2022Review
- Surface chemistry of metal oxide nanoparticles: NMR and TGA quantification.Analytical and bioanalytical chemistry · 2022Article
- Influence of Pre-Dispersion Media on the Batch Reactor Dissolution Behavior of AlNanomaterials (Basel, Switzerland) · 2022Article
- Validation and Demonstration of an Atmosphere-Temperature-pH-Controlled Stirred Batch Reactor System for Determination of (Nano)Material Solubility and Dissolution Kinetics in Physiological Simulant Lung Fluids.Nanomaterials (Basel, Switzerland) · 2022Article
- Release of particulate matter from nano-enabled building materials (NEBMs) across their lifecycle: Potential occupational health and safety implications.Journal of hazardous materials · 2022Article
- Analyzing the surface of functional nanomaterials-how to quantify the total and derivatizable number of functional groups and ligands.Mikrochimica acta · 2021Review
- In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT.Particle and fibre toxicology · 2021Article
- A Multi-Method Approach for Quantification of Surface Coatings on Commercial Zinc Oxide Nanomaterials.Nanomaterials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Manufactured nanomaterials (MNMs) often have a surface-chemical modification in order to tailor their physicochemical properties, including also powder properties and miscibility. Surface-chemical modifications may influence the toxicological properties of the MNM, but the specific chemistry and extent are rarely described in detail in suppliers' technical data sheets. Chemical and quantitative information on any surface-chemical treatment, coating and functionalization are required for chemicals registration in Europe. Currently there is no globally accepted and documented approach to generate such data. Consequently, there is a continued research need to establish a structured approach to identify and quantify surface-chemical modifications. Here we present a tiered approach starting with screening for mass-loss during heating in a furnace or thermogravimetric analysis (TGA) followed by solvent extraction, and analysis by several mass spectrometry (MS) techniques depending on the target analytes. Thermal treatment was assumed to be able to quantify the amount of organic coating and MS was used to identify the extractable organic coatings after pressurized liquid extraction (PLE) using methanol at 200 °C. Volatile organic compounds in extracts were identified with gas chromatography and MS (GC-MS), non-volatile organic compounds with liquid chromatography MS (LC-MS), and polymeric compounds with matrix-assisted laser desorption ionization time-of-flight MS (MALDI-TOF-MS). The approach was demonstrated by analysis of 24 MNM, comprising titanium dioxide, synthetic amorphous silica, graphite, zinc oxide, silver, calcium carbonate, iron oxide, nickel-zinc-iron oxide, and organoclay. In extracts of 14 MNMs a range of organic compounds were identified and the main groups were silanes/siloxanes, fatty acids, fatty acid esters, quaternary ammonium compounds and polymeric compounds. In the remaining 10 MNMs no organic compounds were detected by MS, despite the fact an organic coating was indicated by TGA.
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