Evidence map›Paper›PMID 31698879›Full record

ArticleBrain sciences2019

Impact of Polymorphisms in the Serotonin Transporter Gene on Oscillatory Dynamics during Inhibition of Planned Movement in Children.

Andrey V Bocharov, Alexander N Savostyanov, Sergey S Tamozhnikov, Alexander E Saprigyn, Ekaterina A Proshina, Tatiana N Astakhova, Gennady G Knyazev

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrey V BocharovLaboratory of Psychophysiology of Individual Differences, Institute of Physiology and Basic Medicine, 630117 Novosibirsk, Russia.
Alexander N SavostyanovLaboratory of Psychophysiology of Individual Differences, Institute of Physiology and Basic Medicine, 630117 Novosibirsk, Russia.
Sergey S TamozhnikovLaboratory of Psychophysiology of Individual Differences, Institute of Physiology and Basic Medicine, 630117 Novosibirsk, Russia.
Alexander E SaprigynLaboratory of Psychophysiology of Individual Differences, Institute of Physiology and Basic Medicine, 630117 Novosibirsk, Russia.
Ekaterina A ProshinaLaboratory of Psychophysiology of Individual Differences, Institute of Physiology and Basic Medicine, 630117 Novosibirsk, Russia.
Tatiana N AstakhovaHumanitarian Institute, Novosibirsk State University, 630090 Novosibirsk, Russia.
Gennady G KnyazevLaboratory of Psychophysiology of Individual Differences, Institute of Physiology and Basic Medicine, 630117 Novosibirsk, Russia.
Institute of Physiology and Basic Medicine · RUNovosibirsk State University · RU

Funding

project of the Ministry of Science and Higher Education of the Russian Federation 28.12487.2018/12.1Russian Foundation for Basic Research (RFBR) 17-06-00055Russian Foundation for Basic Research (RFBR) 18-29-13027
6 · The paper itself

Abstract

The serotonin transporter plays an important role in serotonergic neuromodulation. It is known that polymorphisms in the serotonin transporter gene are linked to the dysregulation of emotions. In the current study, we aimed to investigate the impact of variation in the gene encoding serotonin transporter polymorphism on oscillatory dynamics during inhibition of planned movement in the stop signal paradigm. During performance the stop signal paradigm, electroencephalograms (EEGs) were recorded in 90 healthy Caucasian children (39 girls) from 7 to 12 years. Buccal epithelium probes were taken from all participants. The La, Lg, and S alleles of serotonin transporter-linked polymorphic region (5-HTTLPR) polymorphism were detected in the DNA samples using PCR. LaLa genotype carriers did not differ from LaS\LgS and LgS\LgLg\SS carriers in a number of successful inhibitions of a prepotent response. Carriers of LaLa exhibit higher alpha and beta event-related spectral perturbations (ERSP) in parietal and occipital cortices after the presentation of signal of inhibition of movement than LaS\LgS and LgS\LgLg\SS carriers. Results are consistent with current literature and confirm that S allele carriers are more predisposed to disturbances in cognitive control.

Indexed as

alpha oscillationsbeta oscillationsinhibitionserotonin transporter polymorphismstop signal paradigm

Identifiers

PMID31698879
PMCPMC6896020
OpenAlexW2989289886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.