Evidence map›Paper›PMID 31698867›Full record

ArticleJournal of clinical medicine2019

Associations between Plasma Biomarkers and Cognition in Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment: A Cross-Sectional and Longitudinal Study.

Chia-Lin Tsai, Chih-Sung Liang, Jiunn-Tay Lee, Ming-Wei Su, Chun-Chieh Lin, Hsuan-Te Chu, Chia-Kuang Tsai, Guan-Yu Lin, Yu-Kai Lin, Fu-Chi Yang

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. AD-related plasma biomarkers in centenarians: links to cognition and neuropathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  3. Article
  4. Article
  5. Blood biomarkers differentiate AD-related versus non-AD-related cognitive deficits.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Plasma p-tauAlzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
  13. Clinical significance of the cognition-related pathogenic proteins in plasma neuronal-derived exosomes among normal cognitive adults over 45 years old with olfactory dysfunction.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. The global Alzheimer's Association round robin study on plasma amyloid β methods.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Chia-Lin TsaiDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Chih-Sung LiangDepartment of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei 112, Taiwan.
Jiunn-Tay LeeDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Ming-Wei SuInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Chun-Chieh LinDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Hsuan-Te ChuDepartment of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei 112, Taiwan.
Chia-Kuang TsaiDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Guan-Yu LinDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Yu-Kai LinDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Fu-Chi YangDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Tri-Service General Hospital · TWInstitute of Biomedical Sciences, Academia Sinica · TW

Funding

Ministry of Science and Technology, Taiwan MOST 105-2314-B-016-004-Ministry of Science and Technology, Taiwan MOST 106-2314-B-016-007-MY2Ministry of Science and Technology, Taiwan MOST 108-2314-B-016-020-Ministry of Science and Technology, Taiwan MOST 108-2314-B-016-023-Tri-Service General Hospital TSGH-C101-159Tri-Service General Hospital TSGH-C106-068Tri-Service General Hospital TSGH-C108-100Tri-Service General Hospital TSGH-C108-216
6 · The paper itself

Abstract

Brain degeneration in patients with Alzheimer's disease (AD) results from the accumulation of pathological amyloid- (Aβ) plaques and tau protein tangles, leading to altered plasma levels of biomarkers. However, few studies have investigated the association between plasma biomarkers and cognitive impairment in patients with AD. In this cross-sectional study, we investigated correlations between mini-mental state examination (MMSE) scores and levels of plasma biomarkers in patients with amnestic mild cognitive impairment (aMCI) and AD. Thirteen individuals with normal cognition, 40 patients with aMCI, and 37 patients with AD were enrolled. Immunomagnetic reduction was used to assess the levels of plasma biomarkers, including amyloid A

Indexed as

Alzheimer’s diseaseamnestic mild cognitive impairmentimmunomagnetic reductionplasma biomarkers

Identifiers

PMID31698867
PMCPMC6912664
OpenAlexW2988959027

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.