Evidence map›Paper›PMID 31698822›Full record

ArticleMolecules (Basel, Switzerland)2019

Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK).

Christopher R M Asquith, James M Bennett, Lianyong Su, Tuomo Laitinen, Jonathan M Elkins, Julie E Pickett, Carrow I Wells, Zengbiao Li, Timothy M Willson, William J Zuercher

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Christopher R M AsquithStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-5871-3458
James M BennettStructural Genomics Consortium and Target Discovery Institute, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, UK.
Lianyong SuDrumetix Laboratories, Greensboro, NC 27409, USA.
Tuomo LaitinenSchool of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Jonathan M ElkinsStructural Genomics Consortium and Target Discovery Institute, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, UK.
Julie E PickettStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Carrow I WellsStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Zengbiao LiDrumetix Laboratories, Greensboro, NC 27409, USA.
Timothy M WillsonStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
William J ZuercherStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-9836-0068
University of North Carolina at Chapel Hill · USUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Eastern Finland · FIUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SGC-GAK-1 (

Indexed as

Cluster AnalysisCyclic GMP-Dependent Protein KinasesModels, MolecularMolecular StructureProtein ConformationProtein Kinase InhibitorsStructure-Activity RelationshipCyclic GMP-Dependent Protein KinasesProtein Kinase Inhibitors1-aminobenzotriazole (ABT)cyclin G associated kinase (GAK)in vivo kinase designkinase inhibitor design

Identifiers

PMID31698822
PMCPMC6891286
OpenAlexW2988725855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.