Evidence map›Paper›PMID 31698783›Full record

ReviewInternational journal of molecular sciences2019

Cationic Surfactants: Self-Assembly, Structure-Activity Correlation and Their Biological Applications.

Lucia Ya Zakharova, Tatiana N Pashirova, Slavomira Doktorovova, Ana R Fernandes, Elena Sanchez-Lopez, Amélia M Silva, Selma B Souto, Eliana B Souto

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
7.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 164 citations in OpenAlex.

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  12. Effects ofArhiv za higijenu rada i toksikologiju · 2025
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  15. Greywater Reuse: Contaminant Profile, Health Implications, and Sustainable Solutions.International journal of environmental research and public health · 2025
    Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Lucia Ya ZakharovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, 8, ul. Arbuzov, 420088 Kazan, Russia.
Tatiana N PashirovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, 8, ul. Arbuzov, 420088 Kazan, Russia.
Slavomira DoktorovovaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
Ana R FernandesDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
Elena Sanchez-LopezDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
Amélia M SilvaDepartment of Biology and Environment, School of Life and Environmental Sciences, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.
Selma B SoutoDepartment of Endocrinology of S. João Hospital, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
Eliana B SoutoDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
University of Coimbra · PTA.E. Arbuzov Institute of Organic and Physical Chemistry · RUBiomedical Research Networking Center on Neurodegenerative Diseases · ESHospital de São João · PTUniversity of Trás-os-Montes and Alto Douro · PT

Funding

PLANT MOLECULAR RESPONSE TO RHIZOBIUM EXOPOLYSACCHARIDEF06TW001973 · FIC · UNIVERSITY OF WASHINGTON · PI LEIGH, JOHN A · 1993 to 1993
–
Portuguese Science and Technology Foundation (FCT) Grants no. SFRH/BPD/101650/2014, SFRH/BD/130555/2017, M-ERA-NET/0004/2015 (PAIRED)Russian Scientific Foundation Grant no. 19-73-30012
6 · The paper itself

Abstract

The development of biotechnological protocols based on cationic surfactants is a modern trend focusing on the fabrication of antimicrobial and bioimaging agents, supramolecular catalysts, stabilizers of nanoparticles, and especially drug and gene nanocarriers. The main emphasis given to the design of novel ecologically friendly and biocompatible cationic surfactants makes it possible to avoid the drawbacks of nanoformulations preventing their entry to clinical trials. To solve the problem of toxicity various ways are proposed, including the use of mixed composition with nontoxic nonionic surfactants and/or hydrotropic agents, design of amphiphilic compounds bearing natural or cleavable fragments. Essential advantages of cationic surfactants are the structural diversity of their head groups allowing of chemical modification and introduction of desirable moiety to answer the green chemistry criteria. The latter can be exemplified by the design of novel families of ecological friendly cleavable surfactants, with improved biodegradability, amphiphiles with natural fragments, and geminis with low aggregation threshold. Importantly, the development of amphiphilic nanocarriers for drug delivery allows understanding the correlation between the chemical structure of surfactants, their aggregation behavior, and their functional activity. This review focuses on several aspects related to the synthesis of innovative cationic surfactants and their broad biological applications including antimicrobial activity, solubilization of hydrophobic drugs, complexation with DNA, and catalytic effect toward important biochemical reaction.

Indexed as

CationsDrug Delivery SystemsHydrophobic and Hydrophilic InteractionsNanostructuresStructure-Activity RelationshipSurface-Active AgentsCationsSurface-Active Agents1,4-diazabicyclo[2.2.2]octaneantimicrobial nanocarrierscationic surfactantsdrug delivery systemsself-assemblysolubilization

Identifiers

PMID31698783
PMCPMC6888607
OpenAlexW2988662118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.