Evidence map›Paper›PMID 31698692›Full record

ReviewNon-coding RNA2019

Assembly and Function of Gonad-Specific Non-Membranous Organelles in

Shigeki Hirakata, Mikiko C Siomi

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Non-coding RNA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. How germ granules promote germ cell fate.Nature reviews. Genetics · 2024
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Epigenetics and genome stability.Mammalian genome : official journal of the International Mammalian Genome Society · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shigeki HirakataDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0032, Japan.
Mikiko C SiomiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0032, Japan.ORCID 0000-0002-6149-4396
The University of Tokyo · JP

Funding

Ministry of Education, Culture, Sports, Science and Technology 19H05466
6 · The paper itself

Abstract

PIWI-interacting RNAs (piRNAs) are small non-coding RNAs that repress transposons in animal germlines. This protects the genome from the invasive DNA elements. piRNA pathway failures lead to DNA damage, gonadal development defects, and infertility. Thus, the piRNA pathway is indispensable for the continuation of animal life. piRNA-mediated transposon silencing occurs in both the nucleus and cytoplasm while piRNA biogenesis is a solely cytoplasmic event. piRNA production requires a number of proteins, the majority of which localize to non-membranous organelles that specifically appear in the gonads. Other piRNA factors are localized on outer mitochondrial membranes. In situ RNA hybridization experiments show that piRNA precursors are compartmentalized into other non-membranous organelles. In this review, we summarize recent findings about the function of these organelles in the

Indexed as

Dot COMDrosophilaFlam bodymitochondrionnuageovarypiRNAPIWItransposonYb body

Identifiers

PMID31698692
PMCPMC6958439
OpenAlexW2983030753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.