ArticleEnvironmental microbiology2019
The identification and deletion of the polyketide synthase-nonribosomal peptide synthase gene responsible for the production of the phytotoxic triticone A/B in the wheat fungal pathogen Pyrenophora tritici-repentis.
Article in Environmental microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Discovery of Two Novel Phthalide Phytotoxins from the Wheat Tan Spot Fungal PathogenJournal of agricultural and food chemistry · 2024Article
- Molecular Phylogenetic and Comparative Genomic Analysis ofJournal of fungi (Basel, Switzerland) · 2024Article
- Spatiotemporal patterns of wheat response to Pyrenophora tritici-repentis in asymptomatic regions revealed by transcriptomic and X-ray fluorescence microscopy analyses.Journal of experimental botany · 2023Article
- Genetics and breeding for resistance against four leaf spot diseases in wheat (Frontiers in plant science · 2023Review
- A putative terpene cyclase gene (Frontiers in microbiology · 2023Article
- Defence-related metabolic changes in wheat (Frontiers in plant science · 2023Article
- Bioactive Metabolite Production in the GenusToxins · 2022Review
- A polyketide synthase from Verticillium dahliae modulates melanin biosynthesis and hyphal growth to promote virulence.BMC biology · 2022Article
- Article
- Hierarchical clustering of MS/MS spectra from the firefly metabolome identifies new lucibufagin compounds.Scientific reports · 2020Article
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7 authors.
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Abstract
The economically important necrotrophic fungal pathogen, Pyrenophora tritici-repentis (Ptr), causes tan spot of wheat, a disease typified by foliar necrosis and chlorosis. The culture filtrate of an Australian Ptr isolate, M4, possesses phytotoxic activity and plant bioassay guided discovery led to the purification of necrosis inducing toxins called triticone A and B. High-resolution LC-MS/MS analysis of the culture filtrate identified an additional 37 triticone-like compounds. The biosynthetic gene cluster responsible for triticone production (the Ttc cluster) was identified and deletion of TtcA, a hybrid polyketide synthase (PKS)-nonribosomal peptide synthase (NRPS), abolished production of all triticones. The pathogenicity of mutant (ttcA) strains was not visibly affected in our assays. We hypothesize that triticones possess general antimicrobial activity important for competition in multi-microbial environments.
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