ArticleNeurobiology of aging2020
Microglial activation, but not tau pathology, is independently associated with amyloid positivity and memory impairment.
Abstract read
In one paragraph
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Dual association patterns between microglial activation and neuronal health in Alzheimer's disease: a whole-brain MRSI/PET study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Genetic validation of ABI3 p.Ser209Phe variant and its effects on early brain pathology in asymptomatic elderly individuals.Alzheimer's research & therapy · 2026Article
- Longitudinal biomarker studies in human neuroimaging: capturing biological change of Alzheimer's pathology.Alzheimer's research & therapy · 2025Review
- Neuroinflammation PET and long-term cognition and survival in symptomatic Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Amyloid beta and tau are associated with the dual effect of neuroinflammation on neurodegeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Trait-anxiety and glial-related neuroinflammation of the amygdala and its associated regions in Alzheimer's disease: A significant correlation.Brain, behavior, & immunity - health · 2024Article
- Microglia measured by TSPO PET are associated with Alzheimer's disease pathology and mediate key steps in a disease progression model.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- PET Imaging to Measure Neuroinflammation In Vivo.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Non-invasiveFrontiers in cellular neuroscience · 2024Review
- Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies.Molecular psychiatry · 2023Article
- Microglia and cognitive impairment in schizophrenia: translating scientific progress into novel therapeutic interventions.Schizophrenia (Heidelberg, Germany) · 2023Review
- Article
- Vascular Effects on Cerebrovascular Permeability and Neurodegeneration.Biomolecules · 2023Review
- APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly.Alzheimer's research & therapy · 2023Article
- Positron Emission Tomography of Neuroimmune Responses in Humans: Insights and Intricacies.Seminars in nuclear medicine · 2023Review
- Neuroinflammation is independently associated with brain network dysfunction in Alzheimer's disease.Molecular psychiatry · 2023Article
- Clinical heterogeneity of neuro-inflammatory PET profiles in early Alzheimer's disease.Frontiers in neurology · 2023Article
- Essential Principles and Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging.Current medicinal chemistry · 2022Review
- Neuroimmune contributions to Alzheimer's disease: a focus on human data.Molecular psychiatry · 2022Review
- Have (R)-[European journal of nuclear medicine and molecular imaging · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
James ZouTaub Institute, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: jsz2108@cumc.columbia.edu.
Sha TaoMailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA.
Aubrey JohnsonTaub Institute, Columbia University Irving Medical Center, New York, NY, USA.
Zeljko TomljanovicTaub Institute, Columbia University Irving Medical Center, New York, NY, USA.
Krista PollyTaub Institute, Columbia University Irving Medical Center, New York, NY, USA.
Julia KleinTaub Institute, Columbia University Irving Medical Center, New York, NY, USA.
Qolamreza R RazlighiTaub Institute, Columbia University Irving Medical Center, New York, NY, USA.
Adam M BrickmanTaub Institute, Columbia University Irving Medical Center, New York, NY, USA.
Seonjoo LeeMailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA.
Yaakov SternTaub Institute, Columbia University Irving Medical Center, New York, NY, USA.
William Charles KreislTaub Institute, Columbia University Irving Medical Center, New York, NY, USA.
Funding
Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3MResearch Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Christiane Reitz · 2020 to 2026
$30.1MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MVASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MAYEUX, RICHARD P · 1989 to 2008
$21.7MExploring Cognitive Aging Using Reference Ability Neural NetworksR01AG038465 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HABECK, CHRISTIAN GEORG, STERN, YAAKOV · 2011 to 2025
$17.0MImaging of Cognition, Learning and Memory in AgingR01AG026158 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STERN, YAAKOV · 2004 to 2021
$10.9MEpidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1MGenetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9MExploring Cognitive Aging Using Refernce Ability Neural NetworksRF1AG038465 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HABECK, CHRISTIAN GEORG, STERN, YAAKOV · 2016 to 2018
$7.6MWhite Matter Hyperintentisities in Aging and DementiaR56AG034189 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M · 2016 to 2016
$793kImaging inflammation and tau in elders with different clinical and biomarker profiles of Alzheimer’s diseaseK23AG052633 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KREISL, WILLIAM CHARLES · 2016 to 2020
$789kNCATS NIH HHS UL1 TR000040NIA NIH HHS K23 AG052633NIA NIH HHS P01 AG007232NIA NIH HHS P30 AG066462NIA NIH HHS P50 AG008702NIA NIH HHS R01 AG026158NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG038465NIA NIH HHS R56 AG034189NIA NIH HHS RF1 AG038465NIA NIH HHS RF1 AG054023
Abstract
We sought to determine if upstream amyloid accumulation and downstream cognitive impairment have independent relationships with microglial activation and tau pathology. Fifty-eight older adults were stratified by amyloid and cognitive status based on
Indexed as
MicrogliaAgedAged, 80 and overAlzheimer DiseaseAmyloidFemaleHumansMaleMemory DisordersMiddle AgedPositron-Emission Tomographytau ProteinsAmyloidtau ProteinsAlzheimer's diseaseAmyloidMicrogliaNeuroinflammationTau
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.