ArticleExperimental gerontology2020
17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates.
Article in Experimental gerontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Dietary composition and metabolic stress differentially affect the ovarian microenvironment in mice.GeroScience · 2026Article
- VCD-induced estropause fails to enhance responsiveness to 17α-estradiol in adult female mice.GeroScience · 2026Article
- Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice.GeroScience · 2025Article
- A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus).GeroScience · 2025Article
- The profile of steroid hormones in human fetal and adult ovaries.Reproductive biology and endocrinology : RB&E · 2024Article
- 17α-Estradiol alleviates high-fat diet-induced inflammatory and metabolic dysfunction in skeletal muscle of male and female mice.American journal of physiology. Endocrinology and metabolism · 2024Article
- A single-cell atlas of the aging mouse ovary.Nature aging · 2024Article
- Assessing tolerability and physiological responses to 17α-estradiol administration in male rhesus macaques.GeroScience · 2023Article
- Metabolic benefits of 17α-estradiol in liver are partially mediated by ERβ in male mice.Scientific reports · 2023Article
- Metabolic benefits of 17α-estradiol in liver are partially mediated by ERβ in male mice.bioRxiv : the preprint server for biology · 2023Article
- Role of Estrogen Receptor α in Aging and Chronic Disease.Advances in geriatric medicine and research · 2023Article
- The Clinical Application of Growth Hormone and Its Biological and Molecular Mechanisms in Assisted Reproduction.International journal of molecular sciences · 2022Review
- Mild calorie restriction, but not 17α-estradiol, extends ovarian reserve and fertility in female mice.Experimental gerontology · 2022Article
- Reproductive Longevity and Aging: Geroscience Approaches to Maintain Long-Term Ovarian Fitness.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Review
- The Interconnections Between Somatic and Ovarian Aging in Murine Models.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Review
- Growth Hormone and Aging: New Findings.The world journal of men's health · 2021Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Growth hormone receptor knockout mice (GHRKO) have reduced body size and increased insulin sensitivity. These mice are known for having extended lifespan, healthspan and female reproductive longevity. Seventeen α-estradiol (17α-E2) is reported to increase insulin sensitivity and extend lifespan in male mice, with less robust effects in female mice. The aim of this study was to evaluate the ovarian reserve in wild type and GHRKO mice treated with 17α-E2. The mice were divided into four groups, GHRKO mice receiving a standard chow diet, GHRKO mice treated 17α-E2, wild type mice receiving a standard chow diet and WT mice treated with 17α-E2. 17α-E2 was provided in the diet for four months. IGF1 plasma concentrations and changes in body weight were assessed. Histological slides were prepared from the ovaries and the number of follicles was counted. GHRKO mice receiving the control diet had a greater number of primordial follicles and lower numbers of primary follicles compared to the other groups (p < 0.05). 17α-E2 treatment decreased the number of primordial follicles in GHRKO mice (p < 0.05), however had no effect in wild type mice. Treatment with 17α-E2 had no significant effect on the change in body weight during the experiment (p = 0.75). Plasma IGF1 concentrations were significantly lower in GHRKO mice as compared to wild type. In conclusion, we found that GHRKO mice displayed lesser primordial follicle activation as compared to wild type mice, but this phenotype was reversed by 17α-E2 administration, suggesting that ovarian aging is increased by 17α-E2 in long-living mice with extended reproductive longevity.
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Registered trials
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