Evidence map›Paper›PMID 31698021›Full record

ArticleNeuroscience2019

Critical Role of Oxidatively Damaged DNA in Selective Noradrenergic Vulnerability.

Yanqiang Zhan, Muhammad U Raza, Lian Yuan, Meng-Yang Zhu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Parkinson disease-associated cognitive impairment.Nature reviews. Disease primers · 2021
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Yanqiang ZhanDepartment of Neurology, Remin Hospital of the Wuhan University, Wuhan, China.
Muhammad U RazaDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Lian YuanDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Meng-Yang ZhuDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA. Electronic address: zhum@etsu.edu.
East Tennessee State University · USWuhan University · CN

Funding

Restoration of noradrenergic and dopaminergic functions in the brain of aged rats.R15AG055107 · NIA · EAST TENNESSEE STATE UNIVERSITY · PI ZHU, MENG-YANG · 2018 to 2018
$444k
NIA NIH HHS R15 AG055107
6 · The paper itself

Abstract

An important pathology in Parkinson's disease (PD) is the earlier and more severe degeneration of noradrenergic neurons in the locus coeruleus (LC) than dopaminergic neurons in the substantia nigra. However, the basis of such selective vulnerability to insults remains obscure. Using noradrenergic and dopaminergic cell lines, as well as primary neuronal cultures from rat LC and ventral mesencephalon (VM), the present study compared oxidative DNA damage response markers after exposure of these cells to hydrogen peroxide (H

Indexed as

Adrenergic NeuronsAnimalsCalcium Channels, L-TypeCell DeathCells, CulturedCell SurvivalComet AssayCopper Transport ProteinsDNA DamageDNA GlycosylasesDopaminergic NeuronsHumansHydrogen PeroxideLocus CoeruleusMolecular ChaperonesNorepinephrine Plasma Membrane Transport ProteinsATOX1 protein, humanCACNA1C protein, humanCACNA1D protein, humanCalcium Channels, L-TypeCopper Transport ProteinsDNA GlycosylasesHydrogen PeroxideMolecular ChaperonesNorepinephrine Plasma Membrane Transport Proteinsoxoguanine glycosylase 1, humanReactive Oxygen SpeciesSLC6A2 protein, humanCa(2+) channelsDNA damagedopaminedopamine β-hydroxylasenorepinephrinevulnerability

Identifiers

PMID31698021
PMCPMC9338788
OpenAlexW2985634162

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.