Evidence map›Paper›PMID 31698014›Full record

Trial reportAppetite2020

Greater analgesic effects of sucrose in the neonate predict greater weight gain to age 18 months.

Julie C Lumeng, Xing Li, Yunyi He, Ashley Gearhardt, Julie Sturza, Niko A Kaciroti, Ming Li, Katharine Asta, Betsy Lozoff

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Appetite, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02728141 (Timing, Duration and Severity of Infant Iron Deficiency), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02728141 nacompletednot on this map

Timing, Duration and Severity of Infant Iron Deficiency: Developmental Impacts - Sucrose Component

TypeinterventionalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2009 to 2014Enrolled424ConditionsIron DeficiencyArmsWater, Sucrose
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. A narrative review of highly processed food addiction across the lifespan.Progress in neuro-psychopharmacology & biological psychiatry · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Julie C LumengCenter for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA. Electronic address: jlumeng@umich.edu.
Xing LiDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Yunyi HeCenter for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA.
Ashley GearhardtDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Julie SturzaCenter for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA.
Niko A KacirotiCenter for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Ming LiDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Katharine AstaUniversity of Michigan Medical School, Ann Arbor, MI, USA.
Betsy LozoffCenter for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USPeking University First Hospital · CN

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Research BaseP30DK092926 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARY ELLEN MICHELE HEISLER, ADESUWA B OLOMU · 2011 to 2026
$10.0M
Timing, Duration and Severity of Infant Iron Deficiency: Developmental ImpactsR01HD052069 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOZOFF, BETSY · 2007 to 2011
$3.9M
NICHD NIH HHS R01 HD052069NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK092926
6 · The paper itself

Abstract

Intraoral sucrose has analgesic effects in the newborn period. The hedonic and analgesic effects of sucrose overlap and hedonic response to sweet food is associated with adiposity. The potential association between the analgesic effects of intraoral sucrose in the newborn period and subsequent weight gain has not been examined. Healthy, term newborns received 25% intraoral sucrose or water prior to metabolic screen heel stick. Negative affect, quiet alert behavior, and sleepiness were coded during heel stick. Weight and length were measured and z-score (WLZ) calculated at birth, 9, and 18 months. Mixed models tested associations of behavioral response to heel stick with WLZ trajectory among infants receiving sucrose (n = 154) versus water (n = 117). Among infants receiving sucrose prior to heel stick with birth WLZ ≥ the median, less negative affect and more sleepiness during heel stick were each associated with greater increases in WLZ. These associations were not present among infants receiving water only prior to heel stick. Greater analgesic effects of sucrose in the neonate were associated with greater future increases in WLZ, especially among infants with higher birth WLZ. Greater opioid-mediated newborn behavioral response to intraoral sucrose may be a marker for future obesity risk. CLINICAL TRIALS NUMBER: NCT02728141.

Indexed as

AdiposityAnalgesicsBlood Specimen CollectionBody HeightBody WeightDietary SucroseFemaleHumansInfantInfant, NewbornMaleWeight GainAnalgesicsDietary SucroseNeonateObesity

Identifiers

PMID31698014
PMCPMC6954956
OpenAlexW2987644707

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.