ArticleBlood2020
Clonal hematopoiesis in elderly twins: concordance, discordance, and mortality.
Article in Blood, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Mosaic Chromosomal Alterations and Human Longevity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Pooled it
- Genetic influences on haematopoiesis.Nature reviews. Genetics · 2026Review
- Postoperative New-Onset Heart Block in Noncardiac Surgery: Model Development, Validation, and Long-Term Prognostic Analysis.JACC. Asia · 2026Article
- Clonal hematopoiesis at the crossroads of Inflammaging and cardiovascular disease: Mechanistic insights and translational horizons.Clinical hematology international · 2025Review
- Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life.Nature communications · 2024Article
- Case report: Rare case of donor cell-derived T-cell acute lymphoblastic leukaemia in a female patient after receiving an allo-transplant from her male sibling.British journal of haematology · 2023Article
- Molecular Studies for the Early Detection of Philadelphia-Negative Myeloproliferative Neoplasms.International journal of molecular sciences · 2023Review
- Associations Between Cancer Predisposition Mutations and Clonal Hematopoiesis in Patients With Solid Tumors.JCO precision oncology · 2023Article
- Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations.Translational research : the journal of laboratory and clinical medicine · 2023Review
- Clonal Hematopoiesis of Indeterminate Potential in Patients with Solid Tumor Malignancies.Cancer research · 2022Article
- Game of clones: Diverse implications for clonal hematopoiesis in lymphoma and multiple myeloma.Blood reviews · 2022Review
- [Clonal hematopoiesis: causes and clinical implications].Innere Medizin (Heidelberg, Germany) · 2022Article
- Article
- Review
- A predictive model for bone marrow disease in cytopenia based on noninvasive procedures.Blood advances · 2022Article
- In utero origin of myelofibrosis presenting in adult monozygotic twins.Nature medicine · 2022Article
- Clonal Hematopoiesis: Role in Hematologic and Non-Hematologic Malignancies.Mediterranean journal of hematology and infectious diseases · 2022Review
- TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis.Nature communications · 2021Article
- Germline risk of clonal haematopoiesis.Nature reviews. Genetics · 2021Review
- Inflammation in Myeloid Malignancies: From Bench to Bedside.Journal of immunotherapy and precision oncology · 2021Review
Corrections and comments
- Commented on by
- Erratum issued
- Erratum issued
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Clonal hematopoiesis (CH) of indeterminate potential (CHIP) is defined by mutations in myeloid cancer-associated genes with a variant allele frequency of at least 2%. Recent studies have suggested a possible genetic predisposition to CH. To further explore this phenomenon, we conducted a population-based study of 594 twins from 299 pairs aged 73 to 94 years, all with >20 years' follow-up. We sequenced DNA from peripheral blood with a customized 21-gene panel at a median coverage of 6179X. The casewise concordance rates for mutations were calculated to assess genetic predisposition. Mutations were identified in 214 (36%) of the twins. Whereas 20 twin pairs had mutations within the same genes, the exact same mutation was only observed in 2 twin pairs. No significant difference in casewise concordance between monozygotic and dizygotic twins was found for any specific gene, subgroup, or CHIP mutations overall, and no significant heritability could be detected. In pairs discordant for CHIP mutations, we tested if the affected twin died before the unaffected twin, as a direct measurement of the association of having CH when controlling for familial factors. A total of 127 twin pairs were discordant for carrying a mutation, and in 61 (48%) cases, the affected twin died first (P = .72). Overall, we did not find a genetic predisposition to CHIP mutations in this twin study. The previously described negative association of CHIP mutations on survival could not be confirmed in a direct comparison among twin pairs that were discordant for CHIP mutations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.