ArticlePloS one2019
Evaluation of cytological diagnostic accuracy for canine splenic neoplasms: An investigation in 78 cases using STARD guidelines.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 23 citations in OpenAlex.
- Spleens With Disseminated Lymphoma Exhibit Higher Standardized Uptake Value Maximum, Metabolic Tumor Volumes, and Total Lesion Glycolysis on Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026Article
- Ultrasonographic Features and Associated Clinical Findings in 21 Dogs With Histologically Confirmed Abscessed and Non-Abscessed Splenitis.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026Article
- Splenic Lesions in Dogs: A Retrospective Epidemiological and Pathological Study.Veterinary medicine international · 2026Article
- Imaging Diagnosis-Peritoneal Splenosis in a Dog: Computed Tomographic Findings.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026Article
- Large-scale epidemiological and diagnostic assessment of canine cytology in Portugal: insights from 12,671 retrospective cases.Veterinary world · 2025Article
- What Comes from Cytology Diagnosis: A Comprehensive Epidemiological Retrospective Analysis of 3068 Feline Cases.Veterinary sciences · 2025Article
- Acute and chronic systemic inflammation associated with canine nodular splenic lesions composed of heterogeneous cell components: four cases (2020-2024).The Journal of small animal practice · 2025Article
- Article
- Molecular Profile of Canine Hemangiosarcoma and Potential Novel Therapeutic Targets.Veterinary sciences · 2023Review
- Accuracy of B-mode ultrasound and ARFI elastography in predicting malignancy of canine splenic lesions.Scientific reports · 2022Article
- Article
- Validation of digital microscopy: Review of validation methods and sources of bias.Veterinary pathology · 2022Review
- A Machine Learning-Based Approach for Classification of Focal Splenic Lesions Based on Their CT Features.Frontiers in veterinary science · 2022Article
- Peripheral Nerve Sheath Tumors Resembling Human Atypical Neurofibroma in Goldfish (Animals : an open access journal from MDPI · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytology represents a useful diagnostic tool in the preliminary clinical approach to canine splenic lesions, and may prevent unnecessary splenectomy. However, few studies have evaluated diagnostic accuracy of cytology in the diagnosis of canine splenic neoplasms. The aim of this study was to determine overall accuracy, sensitivity, specificity, positive and negative predictive values (i.e. diagnostic accuracy indexes) of cytology for canine splenic neoplasms following Standards for the Reporting of Diagnostic Accuracy Studies (STARD) guidelines. A consecutive series of canine splenic cytological samples was retrospectively retrieved from the database of the Diagnostic Pathology Service of the Department of Veterinary Medicine (DIMEVET-University of Milan). Histopathology was set as the diagnostic reference standard. Cytological cases were enrolled when slides were available for review and when the same lesion was submitted for histopathology. Seventy-eight (78) lesions were included in the study. By histopathology, 56 were neoplastic and 22 were non-neoplastic. Cytology had an overall accuracy of 73.08% (95% C.I. 61.84%-82.50%), sensitivity of 64.29% (95% C.I. 50.36%-76.64%), specificity of 95.45% (95% C.I. 77.16%-99.88%), and positive and negative predictive values of 97.3% (95% C.I. 84.01%-99.60%) and 51.22% (95% C.I. 42.21%-60.15%), respectively. Low sensitivity and negative predictive value were balanced by very high specificity and positive predictive value. When positive for neoplasia, cytology represents a useful diagnostic tool to rule in splenic neoplasia, prompting surgery independently from other diagnostic tests. Conversely, a negative cytological result requires additional investigations to confirm the dog to be disease free.
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