ArticleChemMedChem2020
Structure-Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents.
Article in ChemMedChem, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Perovskone, a potential antiprotozoal hit compound, quantification and derivatization.Scientific reports · 2026Article
- Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof-of-Concept Study.ChemMedChem · 2026Article
- Synthesis of Isobenzofuranones and Isoindolinones via Claisen-Schmidt Condensation and Their Antileishmanial Activity.ACS omega · 2026Article
- Dissecting Structural Requirements of Leucinostatin A Derivatives for Antiprotozoal Activity and Mammalian Toxicity.Journal of medicinal chemistry · 2025Article
- Antiprotozoal activity of natural products from Nigerien plants used in folk medicine.Frontiers in pharmacology · 2023Article
- Efficient One-Pot Synthesis of Novel Caffeic Acid Derivatives as Potential Antimalarials.Journal of parasitology research · 2023Article
- Isolation and Structural Elucidation of Compounds fromMolecules (Basel, Switzerland) · 2022Article
- Identification of Antiprotozoal Compounds fromMolecules (Basel, Switzerland) · 2021Article
- Boswellic Acids Show In Vitro Activity againstMolecules (Basel, Switzerland) · 2021Article
- AntiprotozoalAntibiotics (Basel, Switzerland) · 2021Article
- Article
- Chemical Strategies towards the Synthesis of Betulinic Acid and Its More Potent Antiprotozoal Analogues.Molecules (Basel, Switzerland) · 2021Review
- PrenylatedMolecules (Basel, Switzerland) · 2021Article
- The Alkaloid-Enriched Fraction ofMolecules (Basel, Switzerland) · 2021Article
- Alkyl and Aryl Derivatives Based onMolecules (Basel, Switzerland) · 2020Article
- Structure-Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents.ChemMedChem · 2020Article
- A Comprehensive QSAR Study on Antileishmanial and Antitrypanosomal Cinnamate Ester Analogues.Molecules (Basel, Switzerland) · 2019Article
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Authors and funding
4 authors.
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Abstract
Protozoal infections are still a global health problem, threatening the lives of millions of people around the world, mainly in impoverished tropical and sub-tropical regions. Thus, in view of the lack of efficient therapies and increasing resistances against existing drugs, this study describes the antiprotozoal potential of synthetic cinnamate ester analogues and their structure-activity relationships. In general, Leishmania donovani and Trypanosoma brucei were quite susceptible to the compounds in a structure-dependent manner. Detailed analysis revealed a key role of the substitution pattern on the aromatic ring and a marked effect of the side chain on the activity against these two parasites. The high antileishmanial potency and remarkable selectivity of the nitro-aromatic derivatives suggested them as promising candidates for further studies. On the other hand, the high in vitro potency of catechol-type compounds against T. brucei could not be extrapolated to an in vivo mouse model.
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