ArticleGenome biology and evolution2019
Ancient Introgression between Two Ape Malaria Parasite Species.
Article in Genome biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Review
- Malaria in the 'Omics Era'.Genes · 2021Review
- A Sarcina bacterium linked to lethal disease in sanctuary chimpanzees in Sierra Leone.Nature communications · 2021Article
- Ape Origins of Human Malaria.Annual review of microbiology · 2020Review
- Extracellular Vesicles Could Carry an Evolutionary Footprint in Interkingdom Communication.Frontiers in cellular and infection microbiology · 2020Review
- Host-Malaria Parasite Interactions and Impacts on Mutual Evolution.Frontiers in cellular and infection microbiology · 2020Review
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Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
Abstract
The Laverania clade comprises the human malaria parasite Plasmodium falciparum as well as at least seven additional parasite species that infect wild African apes. A recent analysis of Laverania genome sequences (Otto TD, et al. 2018. Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria. Nat Microbiol. 3: 687-697) reported three instances of interspecies gene transfer, one of which had previously been described. Generating gene sequences from additional ape parasites and re-examining sequencing reads generated in the Otto et al. study, we identified one of the newly described gene transfers as an assembly artifact of sequences derived from a sample coinfected by two parasite species. The second gene transfer between ancestors of two divergent chimpanzee parasite lineages was confirmed, but involved a much larger number of genes than originally described, many of which encode exported proteins that remodel, or bind to, erythrocytes. Because successful hybridization between Laverania species is very rare, it will be important to determine to what extent these gene transfers have shaped their host interactions.
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Registered trials
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