Evidence map›Paper›PMID 31697052›Full record

ArticleAdvanced healthcare materials2019

An Injectable Neural Stimulation Electrode Made from an In-Body Curing Polymer/Metal Composite.

James K Trevathan, Ian W Baumgart, Evan N Nicolai, Brian A Gosink, Anders J Asp, Megan L Settell, Shyam R Polaconda, Kevin D Malerick, Sarah K Brodnick, Weifeng Zeng and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Differential Tissue-Coupled Powering for Battery-Free Injectable Electroceuticals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Advances in Spinal Cord Stimulation.Bioengineering (Basel, Switzerland) · 2023
    Review
  18. Review
  19. Review
  20. A Soft, High-Density Neuroelectronic Array.Npj flexible electronics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

James K TrevathanDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0002-7282-4872
Ian W BaumgartDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Evan N NicolaiDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Brian A GosinkDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Anders J AspMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, 55902, USA.
Megan L SettellDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Shyam R PolacondaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Kevin D MalerickDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Sarah K BrodnickDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Weifeng ZengDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Bruce E KnudsenDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Andrea L McConicoDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55902, USA.
Zachary SangerDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55902, USA.
Jannifer H LeeMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, 55902, USA.
Johnathon M AhoDivision of General Thoracic Surgery, Mayo Clinic, Rochester, MN, 55902, USA.
Aaron J SuminskiDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Erika K RossDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55902, USA.
Jose L LujanMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, 55902, USA.
Douglas J WeberDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Justin C WilliamsDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Manfred FrankeNeuronoff Inc., Valencia, CA, 91354, USA.
Kip A LudwigDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Andrew J ShoffstallDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.

Funding

The Injectrode - A Truly Injectable Electrode for Dorsal Root Ganglion Stimulation to Treat PainU18EB029251 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI LUDWIG, KIP A, WEBER, DOUGLAS J · 2019 to 2021
$2.5M
Defense Advanced Research Projects AgencyNIBIB NIH HHS U18 EB029251NIH HHS 1U18EB029251-01NSF DMR-1720415Space and Naval Warfare Systems Command N66001-17-2-4010
6 · The paper itself

Abstract

Implanted neural stimulation and recording devices hold vast potential to treat a variety of neurological conditions, but the invasiveness, complexity, and cost of the implantation procedure greatly reduce access to an otherwise promising therapeutic approach. To address this need, a novel electrode that begins as an uncured, flowable prepolymer that can be injected around a neuroanatomical target to minimize surgical manipulation is developed. Referred to as the Injectrode, the electrode conforms to target structures forming an electrically conductive interface which is orders of magnitude less stiff than conventional neuromodulation electrodes. To validate the Injectrode, detailed electrochemical and microscopy characterization of its material properties is performed and the feasibility of using it to stimulate the nervous system electrically in rats and swine is validated. The silicone-metal-particle composite performs very similarly to pure wire of the same metal (silver) in all measures, including exhibiting a favorable cathodic charge storage capacity (CSC

Indexed as

Biocompatible MaterialsDielectric SpectroscopyElectrochemistryElectrodesPeripheral NervesPolymersPorosityBiocompatible MaterialsPolymersbiomaterialsinjectrodesneural interfacesneuromodulationperipheral nerves

Identifiers

PMID31697052
PMCPMC10425988

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.