Evidence map›Paper›PMID 31697028›Full record

ArticleAdvanced healthcare materials2020

Controlled Growth Factor Release in 3D-Printed Hydrogels.

Pengrui Wang, David Berry, Amy Moran, Frank He, Trevor Tam, Luwen Chen, Shaochen Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 78 citations in OpenAlex.

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  10. Biomimetic strategies for the deputization of proteoglycan functions.Frontiers in cell and developmental biology · 2024
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  17. Proteoglycans and proteoglycan mimetics for tissue engineering.American journal of physiology. Cell physiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Pengrui WangMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-9185-2951
David BerryDepartment of NanoEngineering, University of California San Diego, La Jolla, CA, 92093, USA.
Amy MoranChemical Engineering Program, University of California San Diego, La Jolla, CA, 92093, USA.
Frank HeDepartment of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Trevor TamDepartment of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Luwen ChenDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093, USA.
Shaochen ChenMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0001-6876-497X
University of California San Diego · US

Funding

Rapid 3D bioprinting of biomimetic vascularized tissue constructsR01EB021857 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN, DOKMECI, MEHMET REMZI · 2016 to 2019
$2.1M
Rapid 3D-printing of Multi-functional Adaptive Nerve ConduitsR33HD090662 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2019 to 2021
$1.1M
3D Printing of Precision Scaffolds for Volumetric Muscle Tissue RegenerationR21AR074763 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2019 to 2020
$355k
NIAMS NIH HHS R21 AR074763NIBIB NIH HHS R01 EB021857NICHD NIH HHS R33 HD090662
6 · The paper itself

Abstract

Growth factors (GFs) are critical components in governing cell fate during tissue regeneration. Their controlled delivery is challenging due to rapid turnover rates in vivo. Functionalized hydrogels, such as heparin-based hydrogels, have demonstrated great potential in regulating GF release. While the retention effects of various concentrations and molecular weights of heparin have been investigated, the role of geometry is unknown. In this work, 3D printing is used to fabricate GF-embedded heparin-based hydrogels with arbitrarily complex geometry (i.e., teabag, flower shapes). Simplified cylindrical core-shell structures with varied shell thickness are printed, and the rates of GF release are measured over the course of 28 days. Increasing the shell layers' thickness decreases the rate of GF release. Additionally, a mathematical model is developed, which is found capable of accurately predicting GF release kinetics in hydrogels with shell layers greater than 0.5 mm thick (R

Indexed as

HeparinHydrogelsIntercellular Signaling Peptides and ProteinsPrinting, Three-DimensionalWound HealingHeparinHydrogelsIntercellular Signaling Peptides and Proteins3D printingcontrolled drug releaseheparinhyaluronic acidhydrogelssequential releasevascular endothelial growth factors

Identifiers

PMID31697028
PMCPMC7202999
OpenAlexW2988253730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.