Evidence map›Paper›PMID 31696925›Full record

ArticleAmerican journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists2019

Tacrolimus trough monitoring guided by mass spectrometry without accounting for assay differences is associated with acute kidney injury in lung transplant recipients.

Nicholas A Kolaitis, Daniel R Calabrese, Patrick Ahearn, Aida Venado, Rebecca Florez, Huey-Ling Lei, Karolina Isaak, Erik Henricksen, Emily Martinez, Tiffany Chong and 10 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Nicholas A KolaitisDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
Daniel R CalabreseDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
Patrick AhearnDivision of Nephrology, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
Aida VenadoDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
Rebecca FlorezSchool of Pharmacy and School of Medicine, University of California, San Francisco, San Francisco, CA.
Huey-Ling LeiDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
Karolina IsaakDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
Erik HenricksenSchool of Pharmacy and School of Medicine, University of California, San Francisco, CA.
Emily MartinezDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
Tiffany ChongDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
Rupal J ShahDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
Lorriana E LeardDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
Mary Ellen KleinhenzDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
Jeffrey GoldenDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
Teresa De MarcoDivision of Cardiology, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
John R GreenlandDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA, and Division of Pulmonary and Critical Care Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, CA.
Jasleen KukrejaDivision of Thoracic Surgery, Department of Surgery, University of California, San Francisco, School of Medicine, San Francisco, CA.
Steven R HaysDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
Paul D BlancDivision of Pulmonary and Critical Care and Division of Occupational and Environmental Medicine, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
Jonathan P SingerDivision of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, School of Medicine, San Francisco, CA.
University of California, San Francisco · USSan Francisco VA Medical Center · US

Funding

MUTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007185 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David J Erle, LAURENCE HUANG · 1985 to 2026
$24.6M
Frailty and patient centered outcomes in candidates for lung transplantationR01HL134851 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SINGER, JONATHAN PAUL · 2017 to 2021
$3.4M
Immune Mechanisms of Large-airway Lymphocytic BronchitisIK2CX001034 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI GREENLAND, JOHN · 2015 to 2019
–
CSRD VA IK2 CX001034NHLBI NIH HHS R01 HL134851NHLBI NIH HHS T32 HL007185
6 · The paper itself

Abstract

purposeTacrolimus is a nephrotoxic immunosuppressant historically monitored via enzyme-based immunoassay (IA). After 2011, the 2 largest laboratory companies in the United States implemented tacrolimus quantification by liquid chromatography-mass spectrometry (LC-MS); this method excludes metabolites, potentially resulting in lower quantified drug concentrations. We sought to determine if tacrolimus therapeutic drug monitoring via LC-MS, as performed using trough targets originally derived from IA values, influences clinical outcomes.

methodsIn a single-center retrospective cohort study of lung transplant recipients, risks of acute kidney injury, acute renal failure, and new-onset diabetes after transplantation, as well as chronic lung allograft dysfunction-free survival, were compared in 82 subjects monitored by LC-MS and 102 subjects monitored by IA using Cox proportional hazard models adjusted for age, sex, baseline renal function, and race.

resultsLC-MS-based monitoring was associated with a greater risk of acute kidney injury (adjusted hazard ratio, 1.65; 95% confidence interval, 1.02-2.67). No statistically significant differences in risks of acute renal failure and new-onset diabetes after transplantation were observed.

conclusionAlthough LC-MS provides a more accurate representation of the blood concentration of the parent compound tacrolimus exclusive of metabolite, established cut points for tacrolimus dosing may need to be adjusted to account for the increased risk of renal injury.

Indexed as

Lung TransplantationTransplant RecipientsAcute Kidney InjuryAgedChromatography, LiquidCohort StudiesFemaleHumansImmunosuppressive AgentsMaleMass SpectrometryMiddle AgedRetrospective StudiesTacrolimusImmunosuppressive AgentsTacrolimusimmunoassayimmunosuppressionkidney injuryliquid chromatographylung transplantationmass spectrometrytacrolimus

Identifiers

PMID31696925
PMCPMC7170730
OpenAlexW2984576394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.