Evidence map›Paper›PMID 31696767›Full record

ReviewRNA biology2020

Translation initiation in mammalian mitochondria- a prokaryotic perspective.

Shreya Ahana Ayyub, Umesh Varshney

Abstract readReview
In one paragraph

Review in RNA biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shreya Ahana AyyubDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Umesh VarshneyDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ATP is generated in mitochondria of eukaryotic cells by oxidative phosphorylation (OXPHOS). The OXPHOS complex, which is crucial for cellular metabolism, comprises of both nuclear and mitochondrially encoded subunits. Also, the occurrence of several pathologies because of mutations in the mitochondrial translation apparatus indicates the importance of mitochondrial translation and its regulation. The mitochondrial translation apparatus is similar to its prokaryotic counterpart due to a common origin of evolution. However, mitochondrial translation has diverged from prokaryotic translation in many ways by reductive evolution. In this review, we focus on mammalian mitochondrial translation initiation, a highly regulated step of translation, and present a comparison with prokaryotic translation.

Indexed as

Peptide Chain Initiation, TranslationalAnimalsDisease SusceptibilityHumansMammalsMitochondriaMitochondrial DiseasesMitochondrial RibosomesModels, MolecularProkaryotic CellsProtein BiosynthesisRibosomesRNA, MessengerRNA, TransferStructure-Activity RelationshipRNA, MessengerRNA, TransferMammalian mitochondriamitochondrial diseasemitoribosomeprotein synthesisribosometranslation initiation

Identifiers

PMID31696767
PMCPMC6973315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.