Evidence map›Paper›PMID 31696671›Full record

Observational studyCancer medicine2020

Reversibility of delirium in Ill-hospitalized cancer patients: Does underlying etiology matter?

Yoshinobu Matsuda, Isseki Maeda, Tatsuya Morita, Toshihiro Yamauchi, Akihiro Sakashita, Hiroaki Watanabe, Keisuke Kaneishi, Koji Amano, Satoru Iwase, Asao Ogawa and 2 more

Open access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Nonpharmacological interventions for preventing delirium in adult patients with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. Pooled it
  3. Observational
  4. Review
  5. The Dilemma of Treating Delirium: the Conundrum of Drug Management.Current treatment options in oncology · 2022
    Review
  6. Article
  7. Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 1 country.

Yoshinobu MatsudaDepartment of Psychosomatic Internal Medicine, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan.ORCID 0000-0001-5092-9377
Isseki MaedaGratia Hospice, Gratia Hospital, Osaka, Japan.
Tatsuya MoritaPalliative and Supportive Care Division, Seirei Mikatahara General Hospital, Shizuoka, Japan.
Toshihiro YamauchiSeirei Hospice, Seirei Mikatahara General Hospital, Shizuoka, Japan.
Akihiro SakashitaDepartment of Palliative Medicine, Kobe University Graduate School of Medicine, Hyogo, Japan.ORCID 0000-0003-0477-8875
Hiroaki WatanabeDepartment of Palliative Care, Komaki City Hospital, Aichi, Japan.
Keisuke KaneishiDepartment of Palliative Care Unit, JCHO Tokyo Shinjuku Medical Center, Tokyo, Japan.
Koji AmanoDepartment of Palliative Medicine, Osaka City General Hospital, Osaka, Japan.
Satoru IwaseDepartment of Palliative Medicine, Saitama Medical University, Saitama, Japan.
Asao OgawaDepartment of Psycho-Oncology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan.ORCID 0000-0003-0436-6934
Kazuhiro YoshiuchiDepartment of Stress Science and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Phase-R Delirium Study Group
Seirei Mikatabara General Hospital · JPChiba Cancer Center · JPKobe University · JPKomaki City Hospital · JPNHO Kinki Chuo Chest Medical Center · JPOsaka City General Hospital · JPSaitama Medical University · JPThe University of Tokyo · JPTokyo Yamate Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this study was to explore the underlying etiologies associated with the resolution and improvement of delirium in ill-hospitalized cancer patients.

methodsWe conducted a secondary analysis of a multicenter, prospective, observational study to estimate the effectiveness of pharmacotherapy for delirium. Participants were cancer patients with delirium. We assessed the Delirium Rating Scale, Revised-98 (DRS-R98) severity scale score at baseline and three days after pharmacotherapy initiation. Delirium resolution was defined as a DRS-R98 severity scale score ≤9, and improvement was defined as ≥50% reduction at Day 3.

resultsWe enrolled 566 patients (491 patients had performance status of 3 or 4). The resolution and improvement rates in all patients were 22.6% and 19.3%, respectively. Univariate analysis determined that nonrespiratory infection (OR 2.18, 95% CI 1.38-3.45) was significantly associated with greater resolution, while dehydration (0.40, 0.19-0.87), organic damage to the central nervous system (CNS) (0.32, 0.43-0.72), hypoxia (0.25, 0.12-0.52), and hyponatremia (0.34, 0.12-0.97) were significantly associated with no resolution. Potential causes associated with delirium improvement were nonrespiratory infection (1.93, 1.19-3.13), organic damage to the CNS (0.40, 0.18-1.90), and hypoxia (0.32, 0.16-0.65). After multivariate analysis, dehydration (0.34, 0.15-0.76), organic damage to the CNS (0.25, 0.10-0.60), and hypoxia (0.29, 0.14-0.61) were significantly associated with no resolution.

conclusionsDelirium caused by nonrespiratory infection may be reversible, while delirium associated with dehydration, organic damage to the CNS, hypoxia, or hyponatremia seems to be irreversible in ill-hospitalized cancer patients.

Indexed as

AgedAged, 80 and overAntipsychotic AgentsCancer Care FacilitiesComorbidityDehydrationDeliriumFemaleHumansHyponatremiaHypoxiaInfectionsMaleMiddle AgedMultivariate AnalysisNeoplasmsAntipsychotic AgentsTrazodonecancercausedeliriumpalliative carereversibility

Identifiers

PMID31696671
PMCPMC6943139
OpenAlexW2986417746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.