ArticleInternational journal of cancer2020
Transcriptome-wide association study reveals candidate causal genes for lung cancer.
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Article in International journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 6 of them syntheses that pooled it.
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46citing papers in PubMed, 6 pooled it
3.8field-weighted citation impact, top 7% of its field
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Who cites it
46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Genome-wide meta-analysis across East Asian and European populations provides insights into the molecular basis of lung cancer.Genome medicine · 2026Pooled it
- Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Pooled it
- Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.Nature communications · 2024Pooled it
- Pooled it
- Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.Nature genetics · 2022Pooled it
- Pooled it
- Aquaporin 3 Promoter Polymorphisms Reduce Gene Expression and Associate Altered Autophagy-Related Gene Signatures With Atopic Dermatitis Susceptibility.Experimental dermatology · 2026Article
- Identifying expression and DNA methylation biomarkers for lung adenocarcinoma risk in East Asia.Journal of the National Cancer Institute · 2026Article
- Single-cell full-length transcriptome of human lung reveals genetic effects on isoform regulation beyond gene-level expression.bioRxiv : the preprint server for biology · 2026Article
- Single-cell lung eQTL dataset of Asian never-smokers highlights the roles of alveolar cells in lung cancer etiology.bioRxiv : the preprint server for biology · 2026Article
- Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention.American journal of human genetics · 2026Article
- Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026Review
- Identification of JAML as an Immune-Associated Prognostic Marker in Non-Small Cell Lung Cancer.Lung Cancer (Auckland, N.Z.) · 2026Article
- A Transcriptome-Wide Association Study Identifies Candidate Susceptibility Loci and Genes for Lung Cancer Risk.Cancer medicine · 2025Article
- Transcriptome-wide association study of alternative polyadenylation identifies susceptibility genes in non-small cell lung cancer.Oncogene · 2025Article
- A Multi-omic study integrating plasma protein, multiple tissues, and single-cell identifies RNASET2 as a key gene for lung cancer.Discover oncology · 2025Article
- Enhancing disease risk gene discovery by integrating transcription factor-linked trans-variants into transcriptome-wide association analyses.Nucleic acids research · 2025Article
- Testing a Large Number of Composite Null Hypotheses Using Conditionally Symmetric Multidimensional Gaussian Mixtures in Genome-Wide Studies.Journal of the American Statistical Association · 2025Article
- Article
- Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes.Nature communications · 2024Article
Corrections and comments
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Authors and funding
48 authors at 20 institutions in 13 countries.
Yohan BosséInstitut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Quebec City, Canada.ORCID 0000-0002-3067-3711
Zhonglin LiInstitut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Quebec City, Canada.
Jun XiaBaylor College of Medicine, The Institute for Clinical and Translational Research, Houston, TX.
Venkata ManemInstitut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Quebec City, Canada.
Robert Carreras-TorresInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Aurélie GabrielInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Nathalie GaudreaultInstitut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Quebec City, Canada.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Melinda C AldrichThoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN.
Angeline AndrewDepartment of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
Susanne ArnoldMarkey Cancer Center, University of Kentucky, Lexington, KY.
Heike BickeböllerDepartment of Genetic Epidemiology, University Medical Center Goettingen, Goettingen, Germany.
Stig E BojesenDepartment of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark.ORCID 0000-0002-4061-4133
Paul BrennanInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Hans BrunnstromClinical Sciences, Lund University, Lund, Sweden.
Neil CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Chu ChenProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
David C ChristianiProgram in Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
John K FieldMolecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme, The University of Liverpool Institute of Translational Medicine, Liverpool, United Kingdom.
Gary GoodmanPublic Health Sciences Division, Swedish Cancer Institute, Seattle, WA.
Kjell GrankvistDepartment of Medical Biosciences, Umeå University, Umea, Sweden.
Richard HoulstonGerman Research Center for Environmental Health, Institute for Cancer Research, London, United Kingdom.
Mattias JohanssonInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Mikael JohanssonDepartment of Radiation Sciences, Umeå University, Umea, Sweden.
Lambertus A KiemeneyRadboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Stephen LamDepartment of Integrative Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.
Maria T LandiNational Cancer Institute, Bethesda, MD.
Philip LazarusDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Pullman, WA.
Loic Le MarchandDepartment of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI.
Geoffrey LiuEpidemiology Division, Princess Margaret Cancer Center, Toronto, ON, Canada.
Olle MelanderClinical Sciences, Lund University, Lund, Sweden.
Gadi RennertTechnion Faculty of Medicine, Carmel Medical Center, Haifa, Israel.
Angela RischCancer Center Cluster Salzburg at PLUS, Department of Molecular Biology, University of Salzburg, Salzburg, Austria.
Susan M RosenbergDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
Matthew B SchabathCancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Sanjay SheteEpidemiology, The University of Texas, MD Anderson Cancer Center, Houston, TX.
Zhuoyi SongDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
Victoria L StevensEpidemiology Research Program, American Cancer Society, Atlanta, GA.
Adonina TardonFaculty of Medicine, University of Oviedo and CIBERESP, Oviedo, Spain.
H-Erich WichmannInstitute of Epidemiology, Helmholtz Center Munich, Oberschleißheim, Germany.
Penella WollAcademic Unit of Clinical Oncology, University of Sheffield, Sheffield, United Kingdom.
Shan ZienolddinyNational Institute of Occupational Health (STAMI), Oslo, Norway.
Ma'en ObeidatThe University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.
Wim TimensDepartment of Pathology and Medical Biology, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Rayjean J HungProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Philippe JoubertInstitut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Quebec City, Canada.
Christopher I AmosBaylor College of Medicine, The Institute for Clinical and Translational Research, Houston, TX.
James D McKayInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Centre international de recherche sur le cancer · FRInstitut universitaire de cardiologie et de pneumologie de Québec · CABaylor College of Medicine · USNational Cancer Institute · USLund University · SEAmerican Cancer Society · USBC Cancer Agency · CACancer Research UK · GBCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZACarmel Medical Center · ILCopenhagen University Hospital · DKDartmouth–Hitchcock Medical Center · USHarvard University · USInstitute of Bioinformatics and Systems Biology · DELunenfeld-Tanenbaum Research Institute · CAMoffitt Cancer Center · USNational Institute of Occupational Health · NONephrologisches Zentrum Goettingen · DEPrincess Margaret Cancer Centre · CARadboud University Nijmegen · NL
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MTranslating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos · 2017 to 2026
$23.7MVirology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI KLINE, MARK W. · 1994 to 2015
$21.7MTHE CAROTENE AND RETINOL EFFICACY TRIAL (CARET)U01CA063673 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 1994 to 2006
$13.0MSPORE in Lung CancerP50CA119997 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GABRILOVICH, DMITRY I · 2008 to 2012
$11.0MStatistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9MTransdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9MCoordinating Center: Molecular and Cellular Findings of Screen-Detected LesionsU01CA196386 · NCI · DARTMOUTH COLLEGE · PI AMOS, CHRISTOPHER I. · 2015 to 2020
$4.1MMechanisms of Endogenous DNA Damage PromotionR01CA250905 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MILLER, KYLE M, ROSENBERG, SUSAN M · 2020 to 2024
$3.3MInfrastructure Support and Pilot Tissue Collection for the CARET BiorepositoryU01CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEUHOUSER, MARIAN L · 2018 to 2022
$2.9MNCI NIH HHS DP1 CA174424NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA076292NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA119997NCI NIH HHS R01 CA250905NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA063673NCI NIH HHS U01 CA167462NCI NIH HHS U01 CA196386NCI NIH HHS U19 CA148127NCI NIH HHS U19 CA203654NCI NIH HHS UM1 CA167462NCRR NIH HHS S10 RR024574NIAID NIH HHS P30 AI036211NIGMS NIH HHS R35 GM122598World Health Organization 001
Abstract
We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal of our study has been to integrate the complete GWAS results with a large-scale expression quantitative trait loci (eQTL) mapping study in human lung tissues (n = 1,038) to identify candidate causal genes for lung cancer. We performed transcriptome-wide association study (TWAS) for lung cancer overall, by histology (adenocarcinoma, squamous cell carcinoma and small cell lung cancer) and smoking subgroups (never- and ever-smokers). We performed replication analysis using lung data from the Genotype-Tissue Expression (GTEx) project. DNA damage assays were performed in human lung fibroblasts for selected TWAS genes. As expected, the main TWAS signal for all histological subtypes and ever-smokers was on chromosome 15q25. The gene most strongly associated with lung cancer at this locus using the TWAS approach was IREB2 (p
Indexed as
Biomarkers, TumorGenetic Predisposition to DiseaseGenome-Wide Association StudyTranscriptomeCell Line, TumorHumansLung NeoplasmsPolymorphism, Single NucleotideQuantitative Trait LociBiomarkers, TumorGWASlung cancerlung eQTLtranscriptome-wide association study
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