ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2019
Comparative Study of Onion (Allium cepa) and Leek (Allium ampeloprasum): Identification of Organosulphur Compounds by UPLC-QTOF/MS and Anticancer Effect on MCF-7 Cells.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
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- Spices and culinary herbs for the prevention and treatment of breast cancer: A comprehensive review with mechanistic insights.Cancer pathogenesis and therapy · 2025Review
- Review
- Effects of different preparation and cooking processes on the bioactive molecules ofFrontiers in nutrition · 2024Review
- Biological features and quality comprehensive analysis of twelve germplasm resources of the genusFrontiers in plant science · 2024Article
- Harnessing the nutraceutical and therapeutic potential ofFrontiers in nutrition · 2024Article
- The efficacy ofAmerican journal of blood research · 2023Article
- Extracts of Common Vegetables Inhibit the Growth of Ovary Cancer Cells.Foods (Basel, Switzerland) · 2022Article
- The Phytochemistry and Pharmacology ofMolecules (Basel, Switzerland) · 2022Review
- Chemical Profiling and Evaluation of Antioxidant and Anticancer Potential of Tuber Crop Amorphophallus commutatus var. wayanadensis.Plant foods for human nutrition (Dordrecht, Netherlands) · 2022Article
- Review
- Recent Advances in Bioactive Compounds, Health Functions, and Safety Concerns of Onion (Frontiers in nutrition · 2021Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Onion (Allium cepa) and leek (Allium ampeloprasum var. porrum) are common herbs and vegetables found in our daily life. It belongs to the genus Allium, which is usually known for their high antioxidant and anticancer properties. Medical researchers highly recommend the exploitation of herbs and plants as alternative ways in the treatment of cancer. This research was designed to study the anticancer effects of onion and leek extracts on MCF-7 human breast cancer cell. Crude extracts of ethanol, methanol, and water of onion and leek were obtained by maceration. MCF-7 cells were cultured in complete media at 37 °C and subjected to different treatments that involved varying concentrations (10, 50, and 100 μg/mL) of onion and leek extracts for 24, 48, and 72 h of incubation. The percentage of cell viability and the concentration of extracts on MCF-7 cells were determined using MTT assay. The water leek extract proved to be the most effective extract at 50 μg/mL, whereby it showed a significant inhibition ability due to the presence of entadamide A-β-D-glucopyranoside as identified by ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UPLC-QTOF/MS). Further studies about the mechanism of both extracts in causing cell death and the determination of the presence of other bioactive compounds in the extracts are needed.
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