ArticleEuropean radiology2020
A nomogram constructed using intraoperative ex vivo shear-wave elastography precisely predicts metastasis of sentinel lymph nodes in breast cancer.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Ex Vivo Shear-Wave Elastography for Intraoperative Prediction of Axillary Lymph Node Metastasis in Breast Cancer.Medicina (Kaunas, Lithuania) · 2026Article
- Dual-mode 3D shear wave elastography with qualitative and quantitative assessment improves diagnosis of inguinal lymph node metastasis.Quantitative imaging in medicine and surgery · 2026Article
- Elasticity Values as a Predictive Modality for Response to Neoadjuvant Chemotherapy in Breast Cancer.Cancers · 2024Article
- Multimodal ultrasound imaging: a method to improve the accuracy of sentinel lymph node diagnosis in breast cancer.Frontiers in oncology · 2024Article
- The effect of the tumor-to-skin distance on axillary lymph node metastasis in breast cancer.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Development and internal validation of a conventional ultrasound-based nomogram for predicting malignant nonmasslike breast lesions.Quantitative imaging in medicine and surgery · 2022Article
- Multi-modality radiomics nomogram based on DCE-MRI and ultrasound images for benign and malignant breast lesion classification.Frontiers in oncology · 2022Article
- Shear Wave Elastography-Assisted Ultrasound Breast Image Analysis and Identification of Abnormal Data.Journal of healthcare engineering · 2022Article
- Feasibility of TEuropean radiology · 2021Article
- Staging of the Axilla in Breast Cancer and the Evolving Role of Axillary Ultrasound.Breast cancer (Dove Medical Press) · 2021Review
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo develop a nomogram and validate its use for the intraoperative evaluation of nodal metastasis using shear-wave elastography (SWE) elasticity values and nodal size
methodsWe constructed a nomogram to predict metastasis using ex vivo SWE values and ultrasound features of 228 axillary LNs from fifty-five patients. We validated its use in an independent cohort comprising 80 patients. In the validation cohort, a total of 217 sentinel LNs were included.
resultsWe developed the nomogram using the nodal size and elasticity values of the development cohort to predict LN metastasis; the area under the curve (AUC) was 0.856 (95% confidence interval (CI), 0.783-0.929). In the validation cohort, 15 (7%) LNs were metastatic, and 202 (93%) were non-metastatic. The mean stiffness (23.54 and 10.41 kPa, p = 0.005) and elasticity ratio (3.24 and 1.49, p = 0.028) were significantly higher in the metastatic LNs than those in the non-metastatic LNs. However, the mean size of the metastatic LNs was not significantly larger than that of the non-metastatic LNs (8.70 mm vs 7.20 mm, respectively; p = 0.123). The AUC was 0.791 (95% CI, 0.668-0.915) in the validation cohort, and the calibration plots of the nomogram showed good agreement.
conclusionsWe developed a well-validated nomogram to predict LN metastasis. This nomogram, mainly based on ex vivo SWE values, can help evaluate nodal metastasis during surgery. KEY POINTS: • A nomogram was developed based on axillary LN size and ex vivo SWE values such as mean stiffness and elasticity ratio to easily predict axillary LN metastasis during breast cancer surgery. • The constructed nomogram presented high predictive performance of sentinel LN metastasis with an independent cohort. • This nomogram can reduce unnecessary intraoperative frozen section which increases the surgical time and costs in breast cancer patients.
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