ReviewCardiovascular research2020
Cardiovascular risk of electronic cigarettes: a review of preclinical and clinical studies.
Review in Cardiovascular research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04974580 (Young Adult Vaping Cessation), which is not on this map. Cited by 72 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Young Adult Vaping Cessation: A Randomized Trial Examining Phone Coaching, Text-based Digital Intervention, and Nicotine Replacement Therapy
Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Electronic Cigarette Use and Blood Pressure Endpoints: a Systematic Review.Current hypertension reports · 2020Pooled it
- Social Media Support Groups for Youth Nicotine Vaping Cessation: An RCT.American journal of preventive medicine · 2026Trial
- Early-onset atherosclerotic cardiovascular disease in young adults: Lifestyle, environmental, and psychosocial risk factors.International journal of cardiology. Cardiovascular risk and prevention · 2026Review
- Interpretable machine learning analysis of routine blood biomarkers and derived indicators for predicting coronary heart disease in patients with carotid stenosis.BMC cardiovascular disorders · 2026Article
- Nicotine influence on cerebrovascular and neurocognitive function with in utero electronic cigarette exposure.The Journal of physiology · 2025Article
- Patterns of E-Cigarette Use Among Cardiac Inpatients at a Tertiary-Care Hospital: A Cross-Sectional Survey.CJC open · 2025Article
- Rising trend of E-cigarettes among adolescents of Pakistan and cardiovascular implications of electronic nicotine delivery systems.World journal of cardiology · 2025Review
- Pregnancy and Postpartum Effects of Electronic Cigarettes on Maternal Health and Vascular Function in the Fourth Trimester.Cardiovascular toxicology · 2025Article
- Electronic cigarette vape decreases nitric oxide bioavailability in vascular smooth muscle cells via increased cytoglobin-mediated metabolism.Free radical biology & medicine · 2025Article
- Daily hassle effects on daily cigarette and/or e-cigarette use: the moderating effect of daily uplifts.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- What Do Dental Students Know About E-Cigarettes? A Cross-Sectional Survey from One Palestinian Dental School.International journal of environmental research and public health · 2024Article
- Review
- Influence of gestational window on offspring vascular health in rodents with in utero exposure to electronic cigarettes.The Journal of physiology · 2024Article
- An electron paramagnetic resonance time-course study of oxidative stress in the plasma of electronic cigarette exposed rats.Experimental physiology · 2024Article
- Electronic Cigarettes and Tobacco Product Cessation: A Survey of Healthcare Providers' Opinions on Safety and Recommendation.Healthcare (Basel, Switzerland) · 2024Article
- Electronic cigarettes and cardiovascular disease: epidemiological and biological links.Pflugers Archiv : European journal of physiology · 2024Review
- A tipping point in dihydroxyacetone exposure: mitochondrial stress and metabolic reprogramming alter survival in rat cardiomyocytes H9c2 cells.Chemico-biological interactions · 2024Article
- Characterization of mass distribution in a biomimetic aerosol exposure system.Inhalation toxicology · 2024Article
- Brazilian Society of Cardiology Position Statement on the Use of Electronic Nicotine Delivery Systems - 2024.Arquivos brasileiros de cardiologia · 2024Article
- The Impact of Heat-Not-Burn, E-Cigarettes, and Cigarettes on Small Airway Function.Tobacco use insights · 2024Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Cigarette smoking is the most preventable risk factor related to cardiovascular morbidity and mortality. Tobacco usage has declined in recent years; however, the use of alternative nicotine delivery methods, particularly e-cigarettes, has increased exponentially despite limited data on their short- and long-term safety and efficacy. Due to their unique properties, the impact of e-cigarettes on cardiovascular physiology is not fully known. Here, we summarize both preclinical and clinical data extracted from short- and long-term studies on the cardiovascular effects of e-cigarette use. Current findings support that e-cigarettes are not a harm-free alternative to tobacco smoke. However, the data are primarily derived from acute studies. The impact of chronic e-cigarette exposure is essentially unstudied. To explore the uniqueness of e-cigarettes, we contemplate the cardiovascular effects of individual e-cigarette constituents. Overall, data suggest that exposure to e-cigarettes could be a potential cardiovascular health concern. Further preclinical research and randomized trials are needed to expand basic and clinical investigations before considering e-cigarettes safe alternatives to conventional cigarettes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.