Evidence map›Paper›PMID 31696161›Full record

ArticleBMC chemistry2019

Abeer J Ayoub, Layal Hariss, Nehme El-Hachem, Ghewa A El-Achkar, Sandra E Ghayad, Oula K Dagher, Nada Borghol, René Grée, Bassam Badran, Ali Hachem and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Abeer J Ayoub *1Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Layal Hariss *3Laboratory for Medicinal Chemistry and Natural Products, Faculty of Sciences I and PRASE-EDST Lebanese University, Beirut, Lebanon.
Nehme El-Hachem *4Integrative Systems Biology, Institut de Recherches Cliniques de Montréal, Montreal, QC Canada.
Ghewa A El-Achkar1Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Sandra E Ghayad5Department of Biology, Faculty of Sciences II, EDST, Lebanese University, Fanar, Lebanon.
Oula K Dagher1Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Nada Borghol2Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences I, Lebanese University, Hadath, Beirut, Lebanon.
René Grée6Université de Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes) UMR 6226, 35000 Rennes, France.
Bassam Badran2Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences I, Lebanese University, Hadath, Beirut, Lebanon.
Ali Hachem *3Laboratory for Medicinal Chemistry and Natural Products, Faculty of Sciences I and PRASE-EDST Lebanese University, Beirut, Lebanon.
Eva Hamade *2Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences I, Lebanese University, Hadath, Beirut, Lebanon.
Aida Habib *1Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.ORCID 0000-0001-6027-0043
Lebanese University · LBAmerican University of Beirut · LBCentre National de la Recherche Scientifique · FRMontreal Clinical Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNew fluorinated diaryl ethers and bisarylic ketones were designed and evaluated for their anti-inflammatory effects in primary macrophages.

methodsThe synthesis of the designed molecules started from easily accessible and versatile

resultsOnly fluorinated compounds exerted anti-inflammatory activities by lowering the secretion of interleukin-6, nitric oxide, and prostaglandin E

conclusionThe new fluorinated diaryl ethers and bisarylic ketones have anti-inflammatory effects in macrophages. These fluorinated compounds have improved potential anti-inflammatory properties due to the fluorine residues in the bioactive molecules.

Indexed as

CyclooxygenaseDiaryl ethersFluorineInflammationMacrophages

Identifiers

PMID31696161
PMCPMC6824041
OpenAlexW2986793659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.