Evidence map›Paper›PMID 31695790›Full record

ArticleTheranostics2019

A novel Granzyme B nanoparticle delivery system simulates immune cell functions for suppression of solid tumors.

Xiaomin Qian, Zhendong Shi, Hongzhao Qi, Ming Zhao, Kai Huang, Donglin Han, Junhu Zhou, Chaoyong Liu, Yang Liu, Yunfeng Lu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 46 citations in OpenAlex.

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  8. CPP Applications in Immune Modulation and Disease Therapy.Methods in molecular biology (Clifton, N.J.) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Xiaomin QianDepartment of Medical Laboratory, School of Medical Technology, Tianjin Medical University, Tianjin 300203, China.
Zhendong Shi3rd Department of Breast Cancer, China Tianjin Breast Cancer Prevention, Treatment and Research center, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
Hongzhao QiTianjin Key Laboratory of Composite and Functional Materials, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China.
Ming ZhaoDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA.
Kai HuangLaboratory of Neuro-Oncology, Tianjin Neurological Institute, Department of Neurosurgery, Tianjin Medical University General Hospital and Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government, Tianjin 300052, China.
Donglin HanTianjin Key Laboratory of Composite and Functional Materials, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China.
Junhu ZhouLaboratory of Neuro-Oncology, Tianjin Neurological Institute, Department of Neurosurgery, Tianjin Medical University General Hospital and Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government, Tianjin 300052, China.
Chaoyong LiuDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA.
Yang LiuDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA.
Yunfeng LuDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA.
Xubo YuanTianjin Key Laboratory of Composite and Functional Materials, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China.
Jin ZhaoTianjin Key Laboratory of Composite and Functional Materials, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China.
Chunsheng KangLaboratory of Neuro-Oncology, Tianjin Neurological Institute, Department of Neurosurgery, Tianjin Medical University General Hospital and Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government, Tianjin 300052, China.
Tianjin University · CNUniversity of California, Los Angeles · USTianjin Medical University General Hospital · CNTianjin Medical University · CNTianjin Medical University Cancer Institute and Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-based immunotherapy for the treatment of hematologic malignancies, such as leukemia and lymphoma, has seen much success and played an increasingly important role in clinical studies. Nevertheless, the efficacy of immunotherapy in solid tumors still needs improvements due to the immunosuppressive properties of tumor cells and the microenvironment. To overcome these limitations, we prepared a novel tumor-targeting delivery system based on the underlying mechanism of immune-targeted cell death that encapsulated granzyme B protein within a porous polymeric nanocapsule.

Indexed as

AnimalsApoptosisCell Line, TumorCell MembraneCell-Penetrating PeptidesDrug Delivery SystemsGranzymesHumansImmune SystemImmunotherapyKiller Cells, NaturalMiceMice, Inbred BALB CMice, NudeNanoparticlesNeoplasmsCell-Penetrating PeptidesGranzymesPerforinbiomimeticsGranzyme B deliverynanoparticlestumor therapy

Identifiers

PMID31695790
PMCPMC6831455
OpenAlexW2982459484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.