Evidence map›Paper›PMID 31695788›Full record

ArticleTheranostics2019

HBX-induced miR-5188 impairs FOXO1 to stimulate β-catenin nuclear translocation and promotes tumor stemness in hepatocellular carcinoma.

Xian Lin, Shi Zuo, Rongcheng Luo, Yonghao Li, Guifang Yu, Yujiao Zou, Yan Zhou, Zhan Liu, Yiyi Liu, Yingying Hu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 100 citations in OpenAlex.

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  11. IncreasedThe Journal of international medical research · 2024
    Article
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  13. Epigenetics and environmental health.Frontiers of medicine · 2024
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Xian LinAffiliated Cancer Hospital & Institute of Guangzhou Medical University; Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Shi ZuoCancer Institute, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, China.
Rongcheng LuoCancer Institute, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, China.
Yonghao LiCancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Guifang YuDepartment of Oncology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Yujiao ZouCancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Yan ZhouBrain Hospital of Hunan Province, Changsha, Hunan, China.
Zhan LiuDepartment of Gastroenterology, Hunan People's Hospital, Changsha, Hunan, China.
Yiyi LiuCancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Yingying HuAffiliated Cancer Hospital & Institute of Guangzhou Medical University; Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Yingying XieCancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Weiyi FangCancer Institute, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, China.
Zhen LiuAffiliated Cancer Hospital & Institute of Guangzhou Medical University; Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
TCM-Intigrated Cancer Center of Southern Medical University · CNGuangzhou Medical University · CNGuiyang Medical University · CNHunan Institute of Mental Health · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer stem cells (CSCs) are the key factor in determining cancer recurrence, metastasis, chemoresistance and patient prognosis in hepatocellular carcinoma (HCC). The role of miR-5188 in cancer stemness has never been documented. In this study, we investigated the clinical and biological roles of miR-5188 in HCC.

Indexed as

Animalsbeta CateninCarcinoma, HepatocellularCell Line, TumorForkhead Box Protein O1Gene Expression Regulation, NeoplasticHep G2 CellsHumansLiver NeoplasmsMaleMiceMice, Inbred BALB CMicroRNAsNeoplasm Recurrence, LocalNeoplastic Stem CellsTrans-Activatorsbeta CateninCTNNB1 protein, humanForkhead Box Protein O1FOXO1 protein, humanhepatitis B virus X proteinMicroRNAsTrans-ActivatorsViral Regulatory and Accessory ProteinsCancer stem cellsHepatitis X proteinHepatocellular carcinomaMiR-5188

Identifiers

PMID31695788
PMCPMC6831466
OpenAlexW2982440388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.