Evidence map›Paper›PMID 31695761›Full record

ArticleTheranostics2019

Gene therapy for hereditary hearing loss by SLC26A4 mutations in mice reveals distinct functional roles of pendrin in normal hearing.

Min-A Kim, Sung Huhn Kim, Nari Ryu, Ji-Hyun Ma, Ye-Ri Kim, Jinsei Jung, Chuan-Jen Hsu, Jae Young Choi, Kyu-Yup Lee, Philine Wangemann and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. A UniqueInternational journal of molecular sciences · 2026
    Article
  5. The Cochlear Lateral Wall as a Biological Battery: the Mechanisms Underlying KJournal of the Association for Research in Otolaryngology : JARO · 2026
    Review
  6. Article
  7. Treating Hearing Loss: From Cochlear Implantation to Gene Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  8. IsMedComm · 2025
    Article
  9. Review
  10. Advancing precision ear medicine: leveraging animal models for disease insights and therapeutic innovations.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
  11. Article
  12. Review
  13. Research hotspots and trends of theIntractable & rare diseases research · 2025
    Article
  14. Review
  15. Review
  16. AAV-mediated Gene Therapy for Hereditary Deafness: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  17. Article
  18. Review
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Min-A KimDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Sung Huhn KimDepartment of Otorhinolaryngology, Head and Neck Surgery, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Nari RyuDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Ji-Hyun MaDepartment of Anatomy, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Ye-Ri KimDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Jinsei JungDepartment of Otorhinolaryngology, Head and Neck Surgery, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Chuan-Jen HsuDepartment of Otolaryngology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Jae Young ChoiDepartment of Otorhinolaryngology, Head and Neck Surgery, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Kyu-Yup LeeDepartment of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
Philine WangemannDepartment of Anatomy and Physiology, Kansas State University, Manhattan, United States of America.
Jinwoong BokDepartment of Otorhinolaryngology, Head and Neck Surgery, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Un-Kyung KimDepartment of Biology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Kyungpook National University · KRYonsei University · KRKansas State University · USNational Taiwan University · TW

Funding

Fluid transport in inner ear developmentR01DC012151 · NIDCD · KANSAS STATE UNIVERSITY · PI WANGEMANN, A. PHILINE · 2012 to 2016
$1.9M
NIDCD NIH HHS R01 DC012151
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genetic TherapyAnimalsCochleaDependovirusEar, InnerEndolymphatic SacEpithelial CellsHair Cells, AuditoryHearingHearing Loss, SensorineuralHydrogen-Ion ConcentrationMice, Inbred C57BLMice, KnockoutMutationOtolithic MembranePhenotypeRNA, MessengerSlc26a4 protein, mouseSulfate TransportersEnlarged vestibular aqueductGene therapyIn-uteroPendred syndromeRecombinant adeno-associated virusSolute carrier family 26 member 4

Identifiers

PMID31695761
PMCPMC6831294
OpenAlexW2977314311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.