Evidence map›Paper›PMID 31695760›Full record

ArticleTheranostics2019

Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8.

Hao-Chen Wang, Yung-Lun Lin, Ching-Cheng Hsu, Ying-Jui Chao, Ya-Chin Hou, Tai-Jan Chiu, Po-Hsien Huang, Ming-Jer Tang, Li-Tzong Chen, Yan-Shen Shan

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Article
  3. Precision immune regulation in KRAS-mutated cancers: the final piece of the puzzle?Journal of experimental & clinical cancer research : CR · 2025
    Review
  4. Review
  5. Article
  6. Inflammation, microbiota, and pancreatic cancer.Cancer cell international · 2025
    Review
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Hao-Chen WangClinical Medicine Research Center, National Cheng Kung University Hospital, Tainan, Taiwan.
Yung-Lun LinInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ching-Cheng HsuInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ying-Jui ChaoInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ya-Chin HouInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Tai-Jan ChiuDepartment of Medical Oncology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Po-Hsien HuangDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ming-Jer TangInternational Research Center of Wound Regeneration & Repair, National Cheng Kung University, Tainan, Taiwan.
Li-Tzong ChenNational Institute of Cancer Research, National Healthy Research Institute, Tainan, Taiwan.
Yan-Shen ShanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
National Cheng Kung University · TWChang Gung University · TWNational Cheng Kung University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Disease ProgressionUp-RegulationAnimalsCell Line, TumorGelsGene Knockdown TechniquesHumansInterleukin-8Low Density Lipoprotein Receptor-Related Protein-1MAP Kinase Signaling SystemMice, TransgenicMutationNeoplasm InvasivenessPancreatic NeoplasmsPancreatic Stellate CellsPlasminogen Activator Inhibitor 1GelsInterleukin-8KRAS protein, humanLow Density Lipoprotein Receptor-Related Protein-1LRP1 protein, humanPlasminogen Activator Inhibitor 1Proto-Oncogene Proteins p21(ras)organotypic coculturePAI-1pancreatic cancerPSCstiffness

Identifiers

PMID31695760
PMCPMC6831292
OpenAlexW2979277373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.