Evidence map›Paper›PMID 31695670›Full record

ArticleFrontiers in neurology2019

Acupuncture Effect and Mechanism for Treating Pain in Patients With Parkinson's Disease.

Shao-Wen Yu, Sung-Han Lin, Chih-Chien Tsai, Kallol Ray Chaudhuri, Yu-Chieh Huang, Yu-Sheng Chen, Bo-Yan Yeh, Yih-Ru Wu, Jiun-Jie Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Efficacy of various acupuncture modalities on alleviating symptoms in Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Review
  9. Article
  10. Observational
  11. Review
  12. Review
  13. Observational
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Shao-Wen YuDivision of Acupuncture and Chinese Traumatology, Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan.
Sung-Han LinMedical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan.
Chih-Chien TsaiMedical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan.
Kallol Ray ChaudhuriParkinson Foundation International Centre of Excellence, King's College Hospital and Kings College, London, United Kingdom.
Yu-Chieh HuangDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Yu-Sheng ChenDivision of Acupuncture and Chinese Traumatology, Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan.
Bo-Yan YehDivision of Acupuncture and Chinese Traumatology, Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan.
Yih-Ru WuDepartment of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Jiun-Jie WangMedical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan.
Chang Gung Memorial Hospital · TWChang Gung University · TWKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-motor symptoms of Parkinson's disease (PD) have been receiving increasing attention. Approximately half of patients with PD have experience PD-related pain. We investigated the effect and mechanism of acupuncture in patients with PD who have pain. PD patients with pain were divided into acupuncture group and control group. Nine patients completed acupuncture treatment; seven patients who received only an analgesic agent underwent resting-state functional magnetic resonance imaging (rs-fMRI) twice. fMRI was performed to evaluate the functional connectivity of the brain regions. After treatment, a decrease in total scores on the King's Parkinson's Disease Pain Scale (KPPS) and Unified Parkinson's Disease Rating Scale was observed in the acupuncture group (-46.2 and -21.6%, respectively). In the acupuncture group, increased connectivity was observed in four connections, one in the left hemisphere between the middle temporal gyrus (MTG) and precentral gyrus, and three in the right hemisphere between the postcentral gyrus and precentral gyrus, supramarginal gyrus and precentral gyrus, and MTG and insular cortex. A significant correlation was noted between the changes in functional connectivity and KPPS. The involved connection was between the left middle frontal gyrus and the right precentral gyrus (

Indexed as

acupuncturefunctional connectivitypainParkinson's diseasers-fMRI

Identifiers

PMID31695670
PMCPMC6817566
OpenAlexW2981450039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.