ArticleFrontiers in physiology2019
Activation and Biological Properties of Human β Defensin 4 in Stem Cells Derived From Human Exfoliated Deciduous Teeth.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Application of an MTT-Based Colorimetric Assay to Evaluate SHED Metabolites in Inhibiting Oral Bacteria Growth.European journal of dentistry · 2026Article
- Molecular mechanism by which mir-153-3p attenuates pulpitis in human deciduous teeth via PTEN-targeted suppression of inflammation and oxidative stress.Odontology · 2026Article
- Immunoinflammatory cells and Beta-defensin-3 in radicular cysts of primary and permanent teeth.Brazilian oral research · 2026Article
- Decoding signaling crosstalk in pulpitis: pathogenesis and precision therapeutics.Frontiers in cell and developmental biology · 2026Review
- Local Defense Factors in Cleft-Affected Palate in Children before and during Milk Dentition Age: A Pilot Study.Journal of personalized medicine · 2023Article
- Biodegradable Polymers and Polymer Composites with Antibacterial Properties.International journal of molecular sciences · 2023Review
- Induction of Endogenous Antimicrobial Peptides to Prevent or Treat Oral Infection and Inflammation.Antibiotics (Basel, Switzerland) · 2023Review
- The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes.Frontiers in cell and developmental biology · 2023Review
- Effect of Biodentine on Odonto/Osteogenic Differentiation of Human Dental Pulp Stem Cells.Bioengineering (Basel, Switzerland) · 2022Article
- Lipid-Based Nano-Sized Cargos as a Promising Strategy in Bone Complications: A Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Therapeutic Potential of Synthetic HumanMediators of inflammation · 2022Article
- Human beta-defensins 2 and 4 are dysregulated in patients with coronavirus disease 19.Microbial pathogenesis · 2021Article
- Multidifferentiation potential of dental-derived stem cells.World journal of stem cells · 2021Review
- Fabrication and Characterization of Calcium-Phosphate Lipid System for Potential Dental Application.Frontiers in chemistry · 2020Article
- Potential Application of Human β-Defensin 4 in Dental Pulp Repair.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulpitis in primary teeth, a condition caused by presence of bacteria, is highly prevalent worldwide. The use of biocompatibility materials with anti-inflammatory, anti-bacterial, and regenerative properties is critical for prognosis of this endodontic disease. This study aimed to identify expression of human β defensin 4 (HBD4) in stem cells derived from human exfoliated deciduous teeth (SHED) and characterize the effects of HBD4 on SHED. Quantitative polymerase chain reaction (qPCR) was used to detect HBD4 expression in SHED and the effect of HBD4 on inflammatory factors in lipopolysaccharide (LPS)-stimulated SHED. Affinity measurement was made by the Fortebio Octet System to explore the potential interaction between LPS and HBD4. Western blot analysis was used to explore the effect of HBD4 on mitogen-activated protein kinase (MAPK) pathway. Colony-forming unit methods and scanning electron microscopy were applied to study antimicrobial effect of HBD4 on
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