Evidence map›Paper›PMID 31695585›Full record

ArticleEJIFCC2019

Evaluation of Visual Serum Indices Measurements and Potential False Result Risks in Routine Clinical Chemistry Tests in Addis Ababa, Ethiopia.

Tigist Getahun, Anberber Alemu, Firehiwot Mulugeta, Merone Sileshi, Abenezer Ayalkebet, Wosene Habtu, Zeleke Geto, Fitsum Girma, Feyissa Challa, Mistire Wolde

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Article in EJIFCC, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Tigist GetahunEthiopian Public Health Institute, National References Laboratory for Clinical Chemistry, Addis Ababa, Ethiopia.
Anberber AlemuEthiopian Public Health Institute, National References Laboratory for Clinical Chemistry, Addis Ababa, Ethiopia.
Firehiwot MulugetaEthiopian Public Health Institute, National References Laboratory for Clinical Chemistry, Addis Ababa, Ethiopia.
Merone SileshiEthiopian Public Health Institute, National References Laboratory for Clinical Chemistry, Addis Ababa, Ethiopia.
Abenezer AyalkebetEthiopian Public Health Institute, National References Laboratory for Clinical Chemistry, Addis Ababa, Ethiopia.
Wosene HabtuEthiopian Public Health Institute, National References Laboratory for Clinical Chemistry, Addis Ababa, Ethiopia.
Zeleke GetoEthiopian Public Health Institute, National References Laboratory for Clinical Chemistry, Addis Ababa, Ethiopia.
Fitsum GirmaEthiopian Public Health Institute, National References Laboratory for Clinical Chemistry, Addis Ababa, Ethiopia.
Feyissa ChallaEthiopian Public Health Institute, National References Laboratory for Clinical Chemistry, Addis Ababa, Ethiopia.
Mistire WoldeDepartment of Medical Laboratory Sciences, Addis Ababa University, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerum indices (SI) including hemolyzed, lipemic, and icteric samples, affects the accuracy of test result. The aim of this study was to evaluate SI values done by visual inspections and potential false result risks by comparing with actual measurements done by Cobas 6000 Chemistry analyzer at Ethiopian Public Health Institute (EPHI), Addis Ababa, Ethiopia.

methodsAn observational, cross-sectional study was conducted from April to May 2017 on samples referred to Clinical Chemistry laboratory of EPHI, Ethiopia. These samples SI values, after visual inspection by three trained observers, was analyzed again on Roche Cobas 6000 analyzer (RCA). The generated data was analyzed by using weighted kappa methods on STAT statistical software version 20.

resultsFrom a total of 1509 samples, SI values identified by the RCA as hemolysis, icteric, and lipemic were 933 (62%), 74(5%) and 59(4%) respectively. The SI average weighted kappa between RCA and visual inspection were: 0.1870, 0.3421, and 0.1259 for hemolysis, icteric, and lipemic samples, respectively. Combined inter-observers variability among observers for hemolysis, Icterus, and lipemic samples were 0.4758, 0.3258, and 0.3628 respectively. The best agreement among observers was in the case of hemolysis (0 grades), while the lowest agreement was observed in the case of icterus (+3 grades). In addition, test parameters, such as CK-MB (22%), and LDH (20%) were falsely accepted, whereas Cl

conclusionVisual inspection of SI showed poorly agreement with automated system. Thus, there is genuine need for more training of Laboratory professionals on identification of SI, and as much as possible SI should be done by automated system to improve quality of test results.

Indexed as

hemolysisictericlipemicserum indices

Identifiers

PMID31695585
PMCPMC6803774

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