Evidence map›Paper›PMID 31695564›Full record

ArticleJournal of ginseng research2019

Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle.

Jinfu Wu, Suchada Saovieng, I-Shiung Cheng, Tiemin Liu, Shangyu Hong, Chang-Yu Lin, I-Chen Su, Chih-Yang Huang, Chia-Hua Kuo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ginseng research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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  14. The effects of resistance training on denervated myofibers, senescent cells, and associated protein markers in middle-aged adults.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Jinfu WuLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Suchada SaoviengLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
I-Shiung ChengLaboratory of Exercise Nutrition, National Taichung University of Education, Taichung, Taiwan.
Tiemin LiuDepartment of Endocrinology and Metabolism, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, China.
Shangyu HongDepartment of Endocrinology and Metabolism, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, China.
Chang-Yu LinLaboratory of Exercise Nutrition, National Taichung University of Education, Taichung, Taiwan.
I-Chen SuGraduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
Chih-Yang HuangGraduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
Chia-Hua KuoLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
University of Taipei · TWFudan University · CNNational Taichung University of Education · TWAsia University · TWChina Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGinsenoside Rg1 has been shown to clear senescence-associated beta-galactosidase (SA-β-gal) in cultured cells. It remains unknown whether Rg1 can influence SA-β-gal in exercising human skeletal muscle.

methodsTo examine SA-β-gal change, 12 young men (age 21 ± 0.2 years) were enrolled in a randomized double-blind placebo controlled crossover study, under two occasions: placebo (PLA) and Rg1 (5 mg) supplementations 1 h prior to a high-intensity cycling (70% VO

resultsNo changes of SA-β-gal were observed after cycling in the PLA trial. On the contrary, nine of the 12 participants showed complete elimination of SA-β-gal in exercised muscle after cycling in the Rg1 trial (

conclusionRg1 supplementation effectively eliminates senescent cells in exercising human skeletal muscle and improves high-intensity endurance performance.

Indexed as

Cellular senescenceEnduranceErgogenic aidInflammationMacrophage

Identifiers

PMID31695564
PMCPMC6823780
OpenAlexW2809551397

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.