ArticleOncoTargets and therapy2019
Investigation Of Small Molecular Substances As Potential Biomarkers For Discrimination Of Gastric Tumor.
Article in OncoTargets and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors at 2 institutions in 1 country.
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Abstract
backgroundGastric tumor (GT) is associated with high morbidity and mortality, with surgery among the most effective treatment methods. Accurate interoperative determination of the tumor margin is crucial.
methodsIn this study, using internal extractive electrospray ionization-MS, mass spectral data of GT and gastric normal (GN) tissues from 36 patients were collected.
resultsIn positive ion detection mode, the relative abundances of m/z 132, 147, 170, and 175 were increased, while the relative abundances of m/z 55, 83, 154, and 203 were decreased in GT tissue. Using partial least squares analysis, the mass spectral data of GT and GN tissues were discriminated, and differential ions (
conclusionFurther investigations of the functions of 5-aminoimidazole and serylproline might provide a better understanding of the underlying mechanisms involved in GT.
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