Evidence map›Paper›PMID 31695368›Full record

ReviewInternational journal of nanomedicine2019

Novel nanomaterial-based antibacterial photodynamic therapies to combat oral bacterial biofilms and infectious diseases.

Manlin Qi, Minghan Chi, Xiaolin Sun, Xianju Xie, Michael D Weir, Thomas W Oates, Yanmin Zhou, Lin Wang, Yuxing Bai, Hockin Hk Xu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 150 citations in OpenAlex.

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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Manlin QiDepartment of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, People's Republic of China.
Minghan ChiDepartment of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, People's Republic of China.
Xiaolin SunDepartment of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, People's Republic of China.
Xianju XieDepartment of Orthodontics, School of Stomatology, Capital Medical University, Beijing, People's Republic of China.
Michael D WeirDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
Thomas W OatesDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
Yanmin ZhouDepartment of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, People's Republic of China.
Lin WangDepartment of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, People's Republic of China.
Yuxing BaiDepartment of Orthodontics, School of Stomatology, Capital Medical University, Beijing, People's Republic of China.
Hockin Hk XuDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
University of Maryland, Baltimore · USJilin University · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral diseases such as tooth caries, periodontal diseases, endodontic infections, etc., are prevalent worldwide. The heavy burden of oral infectious diseases and their consequences on the patients' quality of life indicates a strong need for developing effective therapies. Advanced understandings of such oral diseases, e.g., inflammatory periodontal lesions, have raised the demand for antibacterial therapeutic strategies, because these diseases are caused by viruses and bacteria. The application of antimicrobial photodynamic therapy (aPDT) on oral infectious diseases has attracted tremendous interest in the past decade. However, aPDT had a minimal effect on the viability of organized biofilms due to the hydrophobic nature of the majority of the photosensitizers (PSs). Therefore, novel nanotechnologies were rapidly developed to target the delivery of hydrophobic PSs into microorganisms for the antimicrobial performance improvement of aPDT. This review focuses on the state-of-the-art of nanomaterials applications in aPDT against oral infectious diseases. The first part of this article focuses on the cutting-edge research on the synthesis, toxicity, and therapeutic effects of various forms of nanomaterials serving as PS carriers for aPDT applications. The second part discusses nanomaterials applications for aPDT in treatments of oral diseases. These novel bioactive nanomaterials have demonstrated great potential to serve as carriers for PSs to substantially enhance the PDT therapeutic effects. Furthermore, the novel aPDT applications not only have exciting therapeutic potential to inhibit bacterial plaque-initiated oral diseases, but also have a wide applicability to other biomedical and tissue engineering applications.

Indexed as

PhotochemotherapyAnti-Bacterial AgentsBacterial InfectionsBiofilmsHumansMouthNanostructuresAnti-Bacterial Agentsantibacterialanti-inflammatorynanomaterialsoral diseasesphotodynamic therapyupconversion nanoparticles

Identifiers

PMID31695368
PMCPMC6718167
OpenAlexW2970205866

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.