ReviewJournal of clinical orthopaedics and trauma2019
Osseointegration of osteoporotic bone implants: Role of stem cells, Silica and Strontium - A concise review.
Review in Journal of clinical orthopaedics and trauma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Toxicological and Cytogenetic Screening of Strontium Ranelate Alone and in Combination With Resveratrol.Chemistry & biodiversity · 2026Article
- Rapid mineralization of hydrothermally induced TiOJournal of materials science. Materials in medicine · 2026Article
- An alkaline nanosized platelet vesicle-based hydrogel for the treatment of osteoporotic bone defects.Materials today. Bio · 2026Article
- Sustained release of Sr and Ca from a micronanotopographic titanium surface improves osteoblast function.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- A personalized biomimetic dual-drug delivery system via controlled release of PTHFrontiers in bioengineering and biotechnology · 2024Article
- Assessment of Biotransformed Silica Nanoparticle on Blood Glucose Level in Human: An In Vitro Investigation.Indian journal of clinical biochemistry : IJCB · 2024Article
- Ozone therapy improves early stages of osseointegration in ovariectomized rats.Journal of applied oral science : revista FOB · 2024Article
- Evaluation of Adhesion and Viability of Human Gingival Fibroblasts on Strontium-Coated Titanium Surfaces: an in vitro Study.Clinical, cosmetic and investigational dentistry · 2024Article
- Strontium Functionalization of Biomaterials for Bone Tissue Engineering Purposes: A Biological Point of View.Materials (Basel, Switzerland) · 2022Review
- Advances in Osteoporotic Bone Tissue Engineering.Journal of clinical medicine · 2021Review
- Comparing bone tissue engineering efficacy of HDPSCs, HBMSCs on 3D biomimetic ABM-P-15 scaffolds in vitro and in vivo.Cytotechnology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Osteoporotic fracture treatment has become a skeletal reconstructive challenge due to accelerated bone turnover and impaired bone regeneration potential. Poor osseointegration ability of the osteoporotic bone usually results in implant pull out and failure. Adoption of conventional bone fracture treatment strategies like autografts and allografts have limited applications in such pathological conditions. Hence biomaterials functionalised with therapeutic ions or drugs may be adopted to aid the delivery of therapeutic factors at the defect site to promote bone healing and implant integration, towards functional restoration of the fractured bone. This concise review narrates on improving the osseointegration ability of biomaterials using functional ions like Silica and Strontium. Silica based bone substitutes are known to promote bone healing in non pathological conditions. Further, Strontium based drugs show significant effects in the prevention and treatment of osteoporotic bones. In addition, stem cell therapy has become the focus of orthopaedic research attributed to its ability to restore and accelerate the bone healing process, but the clinical application of stem cells in osteoporotic condition is scarce. Present review suggests a novel strategy of combining the therapeutic potential of functional ions like Silica, Strontium and stem cells within a single implant unit to facilitate osseointegration and osteogenesis, so as to reduce the chances of implant rejection/pull out and encourage osteoporotic bone re-union.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.