Evidence map›Paper›PMID 31695251›Full record

ReviewJournal of clinical and experimental hepatology

Molecular and Pathological Events Involved in the Pathogenesis of Diabetes-Associated Nonalcoholic Fatty Liver Disease.

Onkar Bedi, Savera Aggarwal, Nirupma Trehanpati, Gayatri Ramakrishna, Pawan Krishan

Open access · greenAbstract readReview
In one paragraph

Review in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
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  12. A Plasma Exosomal Metabolic Profiling of Nonalcoholic Fatty Liver Disease Patients Complicated with Impaired Fasting Glucose.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Onkar BediDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.
Savera AggarwalDepartment of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
Nirupma TrehanpatiDepartment of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
Gayatri RamakrishnaDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.
Pawan KrishanDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.
Institute of Liver and Biliary Sciences · INPunjabi University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus is a rising epidemic in most part of the world and is often associated with multiple organ disorders such as kidney, liver, and cardiovascular diseases. Liver is a major metabolic hub, and the metabolic disorders associated with diabetes result in liver dysfunctions culminating in spectrum of liver diseases such as fatty liver disorders, cirrhosis, and hepatocellular carcinoma. The intervention strategies to prevent diabetes-associated liver injury require an overall understanding of the key factors and molecular pathways which can be strategically targeted. The present review focuses on some of the key aspects of fatty acid metabolism, fetuin-A regulation, inflammatory pathways, and genetic factors associated with insulin resistance, dyslipidemia, hyperglycemia, oxidative stress, and so on involved in the nexus between diabetes and liver injury. Further recent interventions, pharmacological target, and newer therapeutic agents are discussed briefly for the better clinical management of diabetes-associated hepatic disorders.

Indexed as

AP-1, Activator protein 1diabetes mellitusdiabetic liver injuryDLI, diabetic liver injuryDM, diabetes mellitusDMPs, Damage-associated molecular patternsFetA, fetuin-Afetuin-AFFA, free fatty acidFOXO1, Forkhead box protein O1free fatty acidG6Pase, Glucose-6-phosphataseHCC, hepatocellular carcinomaIKK, IκB kinaseIL, interleukininflammatory mediatorsIRS2, Insulin receptor substrate-2IκB, Inhibitor of KbLPS, LipopolysaccharideMD2, Myeloid differentiation protein-2MMP, matrix metalloproteinaseMyD88, Myeloid differentiation factor 88NAFLD, nonalcoholic fatty liver diseaseNASH, nonalcoholic steatohepatitisNFe κB, Nuclear factor-κBNIDDM, noninsulin dependent diabetes mellitusPC, Pyruvate carboxylasePEPCK, Phosphoenolpyruvate carboxykinasePIP3, Phosphatidyl inositol (3, 4, 5)-triphosphateT2DM, type 2 diabetes mellitusTh 17, T helper 17 cellsTLR4, Toll-like receptorTNF, tumor necrosis factorVLDL, very low–density lipoprotein

Identifiers

PMID31695251
PMCPMC6823706
OpenAlexW2901406597

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.