ReviewNature2019
Sex and gender analysis improves science and engineering.
Review in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07560982 (Evaluating Adherence to Guideline- Directed Medical Therapy Using the Four-Pillar Strategy in Patients With Advanced Heart Failure), which is not on this map. Cited by 220 papers, 14 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating Adherence to Guideline- Directed Medical Therapy Using the Four-Pillar Strategy in Patients With Advanced Heart Failure: the Advanced Heart Failure Unified Board (Ad-HUB) Study
Who cites it
220 citing papers in PubMed, 14 syntheses or guidelines pooled it, 570 citations in OpenAlex.
- Gender in suicide prevention in adolescents and young adults: a systematic review.BMC public health · 2026Pooled it
- Gender innovation in the scientific evidence on interventions to reduce health inequalities in Europe: an umbrella review.International journal for equity in health · 2026Pooled it
- Exploring the factors associated with professional and non-professional dancer well-being: a comprehensive systematic review.Frontiers in psychology · 2025Pooled it
- Trends in Patient Representation in Low Back Pain Pharmacological Randomized Clinical Trials, 2011 to 2020: A Systematic Review.The journal of pain · 2024Pooled it
- Pooled it
- A Descriptive Review and Meta-Regression Study of Demographic and Study Context Factors in US Clinical Trials of Cognitive Behavioral Interventions for Alcohol or Other Drug Use.Substance use & misuse · 2024Pooled it
- Day and night heart rate variability using 24-h ECG recordings: a systematic review with meta-analysis using a gender lens.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Pooled it
- Do female and male patients derive similar benefits from approved systemic oncology therapies? A systematic review and meta-analysis.Journal of cancer research and clinical oncology · 2023Pooled it
- Deciphering the sex bias in housekeeping gene expression in adipose tissue: a comprehensive meta-analysis of transcriptomic studies.Biology of sex differences · 2023Pooled it
- Shared Components of Worldwide Successful Sexuality Education Interventions for Adolescents: A Systematic Review of Randomized Trials.International journal of environmental research and public health · 2023Pooled it
- Is there a difference in the efficacy of COVID-19 vaccine in males and females? - A systematic review and meta-analysis.Human vaccines & immunotherapeutics · 2021Pooled it
- Identification and inclusion of gender factors in retrospective cohort studies: the GOING-FWD framework.BMJ global health · 2021Pooled it
- Systematic Review of Sex and Gender Effects in Traumatic Brain Injury: Equity in Clinical and Functional Outcomes.Frontiers in neurology · 2021Pooled it
- Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications.eLife · 2020Pooled it
- The Direct and Long-Term Effects of Raloxifene as Adjunctive Treatment for Schizophrenia-Spectrum Disorders: A Double-Blind, Randomized Clinical Trial.Schizophrenia bulletin · 2023Trial
- The cost-effectiveness of adjunctive corticosteroids for patients with septic shock.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2020Trial
- A Framework for Women's Health Engineering Education: Pedagogical Foundations and Practical Implementation.Annals of biomedical engineering · 2026Review
- Article
- Sex-specific biological aging clocks across organs and omics.Nature medicine · 2026Article
- Sex and gender in digital mental health: why the data are not neutral.Women's health nursing (Seoul, Korea) · 2026Review
160 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of sex and gender analysis is to promote rigorous, reproducible and responsible science. Incorporating sex and gender analysis into experimental design has enabled advancements across many disciplines, such as improved treatment of heart disease and insights into the societal impact of algorithmic bias. Here we discuss the potential for sex and gender analysis to foster scientific discovery, improve experimental efficiency and enable social equality. We provide a roadmap for sex and gender analysis across scientific disciplines and call on researchers, funding agencies, peer-reviewed journals and universities to coordinate efforts to implement robust methods of sex and gender analysis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.