Evidence map›Paper›PMID 31695100›Full record

ArticleScientific reports2019

Evaluating differential nanoparticle accumulation and retention kinetics in a mouse model of traumatic brain injury via K

Hunter A Miller, Alexander W Magsam, Aria W Tarudji, Svetlana Romanova, Laura Weber, Connor C Gee, Gary L Madsen, Tatiana K Bronich, Forrest M Kievit

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Sex-based differences of antioxidant enzyme nanoparticle effects following traumatic brain injury.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Article
  7. Nanotherapeutics and the Brain.Annual review of chemical and biomolecular engineering · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hunter A MillerDepartment of Biological Systems Engineering, University of Nebraska, 200 LW Chase Hall, Lincoln, NE, 68583, USA.
Alexander W MagsamDepartment of Biological Systems Engineering, University of Nebraska, 200 LW Chase Hall, Lincoln, NE, 68583, USA.
Aria W TarudjiDepartment of Biological Systems Engineering, University of Nebraska, 200 LW Chase Hall, Lincoln, NE, 68583, USA.
Svetlana RomanovaDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Durham Research Center I, Room 1036, Omaha, NE, 68189, USA.
Laura WeberProTransit Nanotherapy, 16514L St., Omaha, NE, 68135, USA.
Connor C GeeDepartment of Biological Systems Engineering, University of Nebraska, 200 LW Chase Hall, Lincoln, NE, 68583, USA.
Gary L MadsenProTransit Nanotherapy, 16514L St., Omaha, NE, 68135, USA.
Tatiana K BronichDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Durham Research Center I, Room 1036, Omaha, NE, 68189, USA.
Forrest M KievitDepartment of Biological Systems Engineering, University of Nebraska, 200 LW Chase Hall, Lincoln, NE, 68583, USA. fkievit2@unl.edu.ORCID http://orcid.org/0000-0002-9847-783X

Funding

Project 9 - Renal Drug Targeting for the Treatment of Lupus NephritisP20GM103480 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BRONICH, TATIANA K · 2012 to 2017
$13.3M
Nebraska Center for Nanomedicine- Pilot ProjectsP30GM127200 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI OUPICKY, DAVID · 2018 to 2022
$5.7M
NIGMS NIH HHS P20 GM103480NIGMS NIH HHS P30 GM127200
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a leading cause of injury-related death worldwide, yet there are no approved neuroprotective therapies that improve neurological outcome post-injury. Transient opening of the blood-brain barrier following injury provides an opportunity for passive accumulation of intravenously administered nanoparticles through an enhanced permeation and retention-like effect. However, a thorough understanding of physicochemical properties that promote optimal uptake and retention kinetics in TBI is still needed. In this study, we present a robust method for magnetic resonance imaging of nanoparticle uptake and retention kinetics following intravenous injection in a controlled cortical impact mouse model of TBI. Three contrast-enhancing nanoparticles with different hydrodynamic sizes and relaxivity properties were compared. Accumulation and retention were monitored by modelling the permeability coefficient, K

Indexed as

AnimalsBrain Injuries, TraumaticDisease Models, AnimalDrug Delivery SystemsFemaleGadolinium DTPAHumansKineticsMagnetic Resonance ImagingMiceMice, Inbred C57BLNanoparticlesPolylactic Acid-Polyglycolic Acid CopolymerGadolinium DTPAPolylactic Acid-Polyglycolic Acid Copolymer

Identifiers

PMID31695100
PMCPMC6834577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.