Evidence map›Paper›PMID 31695085›Full record

ArticleScientific reports2019

A highly specific and sensitive nanoimmunosensor for the diagnosis of neuromyelitis optica spectrum disorders.

Ariana de Souza Moraes, Doralina Guimarães Brum, Jéssica Cristiane Magalhães Ierich, Akemi Martins Higa, Amanda Stefanie Jabur Assis, Celina Massumi Miyazaki, Flávio Makoto Shimizu, Luís Antonio Peroni, M Teresa Machini, Amilton Antunes Barreira and 3 more

Abstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ariana de Souza MoraesInstitute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, São Paulo, 05403000, Brazil.ORCID http://orcid.org/0000-0001-7453-0133
Doralina Guimarães BrumNanoneurobiophysics research group (GNN), Federal University of São Carlos, Sorocaba, São Paulo, 18052780, Brazil.
Jéssica Cristiane Magalhães IerichInstitute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, São Paulo, 05403000, Brazil.ORCID http://orcid.org/0000-0002-7447-9566
Akemi Martins HigaInstitute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, São Paulo, 05403000, Brazil.
Amanda Stefanie Jabur AssisDepartment of Physics, Chemistry and Mathematics, Federal University of São Carlos, Sorocaba, São Paulo, 18052780, Brazil.
Celina Massumi MiyazakiDepartment of Physics, Chemistry and Mathematics, Federal University of São Carlos, Sorocaba, São Paulo, 18052780, Brazil.
Flávio Makoto ShimizuSão Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo, 13560970, Brazil.
Luís Antonio PeroniRheabiotech Laboratory of Research and Development, Campinas, São Paulo, 13084791, Brazil.ORCID http://orcid.org/0000-0002-3544-8986
M Teresa MachiniDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, 05508000, Brazil.
Amilton Antunes BarreiraDepartment of Neurosciences and Behavioural Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Marystela FerreiraDepartment of Physics, Chemistry and Mathematics, Federal University of São Carlos, Sorocaba, São Paulo, 18052780, Brazil.ORCID http://orcid.org/0000-0002-9459-8167
Osvaldo N OliveiraSão Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo, 13560970, Brazil.
Fabio Lima LeiteDepartment of Physics, Chemistry and Mathematics, Federal University of São Carlos, Sorocaba, São Paulo, 18052780, Brazil. fabioleite@ufscar.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A precise diagnosis for neuromyelitis optica spectrum disorders (NMOSD) is crucial to improve patients' prognostic, which requires highly specific and sensitive tests. The cell-based assay with a sensitivity of 76% and specificity of 100% is the most recommended test to detect anti-aquaporin-4 antibodies (AQP4-Ab). Here, we tested four AQP4 external loop peptides (AQP4

Indexed as

Biosensing TechniquesLab-On-A-Chip DevicesMicroscopy, Atomic ForceSurface Plasmon ResonanceAmino Acid SequenceAntibodies, ImmobilizedAntibody SpecificityAntigen-Antibody ReactionsAquaporin 4AutoantibodiesAutoantigensEquipment DesignHumansImmobilized ProteinsImmunoglobulin GMultiple SclerosisAntibodies, ImmobilizedAQP4 protein, humanAquaporin 4AutoantibodiesAutoantigensImmobilized ProteinsImmunoglobulin GPeptide Fragments

Identifiers

PMID31695085
PMCPMC6834626

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.