Evidence map›Paper›PMID 31695071›Full record

ArticleScientific reports2019

Structural Features of a Conformation-dependent Antigen Epitope on ORFV-B2L Recognized by the 2E4 mAb.

Yongzhong Yu, Wenbo Zhao, Qiang Tan, Xue Zhang, Mengyao Wang, Xuyang Duan, Yuanyuan Liu, Zhijun Wu, Jinzhu Ma, Baifen Song and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Identification of a Novel Linear B-Cell Epitope of HbpA Protein fromInternational journal of molecular sciences · 2023
    Article
  3. NPJ vaccines · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Yongzhong YuVirology Laboratory, College of Biological Science and Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng road, Daqing, 163319, China. yyz1968@126.com.ORCID http://orcid.org/0000-0001-8945-7573
Wenbo ZhaoVirology Laboratory, College of Biological Science and Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng road, Daqing, 163319, China.
Qiang TanVirology Laboratory, College of Biological Science and Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng road, Daqing, 163319, China.
Xue ZhangVirology Laboratory, College of Biological Science and Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng road, Daqing, 163319, China.
Mengyao WangVirology Laboratory, College of Biological Science and Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng road, Daqing, 163319, China.
Xuyang DuanVirology Laboratory, College of Biological Science and Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng road, Daqing, 163319, China.
Yuanyuan LiuVirology Laboratory, College of Biological Science and Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng road, Daqing, 163319, China.
Zhijun WuVirology Laboratory, College of Biological Science and Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng road, Daqing, 163319, China.
Jinzhu MaVirology Laboratory, College of Biological Science and Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng road, Daqing, 163319, China.
Baifen SongVirology Laboratory, College of Biological Science and Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng road, Daqing, 163319, China.
Rui ZhaoPharmacology laboratory, Heilongjiang Bayi Agricultural University, 5 Xinfeng road, Daqing, 163319, China.
Kui ZhaoCollege of Animal Science and Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun, 130062, China.
Zhengxing LianBeijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Yudong CuiVirology Laboratory, College of Biological Science and Technology, Heilongjiang Bayi Agricultural University, 5 Xinfeng road, Daqing, 163319, China. cuiyudong@yahoo.com.
Heilongjiang Bayi Agricultural University · CNChina Agricultural University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, we successfully prepared a monoclonal antibody (mAb) named 2E4, that directly recognizes the major envelope protein B2L of the orf virus (ORFV), but there is little information about its epitope. Here, we meticulously mapped the 2E4 epitope through combinatorial programs and identified the functional binding domain and a key amino acid residue. Briefly, the simulated epitope peptide closely resembles

Indexed as

Amino Acid SequenceAntibodies, MonoclonalEpitope MappingEpitopesOrf virusProtein ConformationViral Envelope ProteinsAntibodies, MonoclonalEpitopesViral Envelope Proteins

Identifiers

PMID31695071
PMCPMC6834619
OpenAlexW2984058497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.