ArticleNature communications2019
A microfluidic-induced C. elegans sleep state.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Application ofBiomolecules & therapeutics · 2026Review
- Predation by nematode-trapping fungus triggers mechanosensory-dependent quiescence iniScience · 2025Article
- Article
- Phototaxis is a satiety-dependent behavioral sequence in Hydra vulgaris.The Journal of experimental biology · 2024Article
- Automated dual olfactory device for studying head/tail chemosensation inAPL bioengineering · 2024Article
- Glia in Invertebrate Models: Insights from Caenorhabditis elegans.Advances in neurobiology · 2024Review
- A sleep-active neuron can promote survival while sleep behavior is disturbed.PLoS genetics · 2023Article
- Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices.BME frontiers · 2023Review
- Article
- Intracellular CaiScience · 2022Article
- Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance ineLife · 2022Article
- Article
- Multiple neuronal networks coordinateeLife · 2021Article
- Sleep Analysis in AdultThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Behavioral States.Genetics · 2020Review
- C. elegans episodic swimming is driven by multifractal kinetics.Scientific reports · 2020Article
- Bioelectronics for Millimeter-Sized Model Organisms.iScience · 2020Review
- A quiescent state following mild sensory arousal in Caenorhabditis elegans is potentiated by stress.Scientific reports · 2020Article
- Discriminating between sleep and exercise-induced fatigue using computer vision and behavioral genetics.Journal of neurogeneticsArticle
- Article
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
Abstract
An important feature of animal behavior is the ability to switch rapidly between activity states, however, how the brain regulates these spontaneous transitions based on the animal's perceived environment is not well understood. Here we show a C. elegans sleep-like state on a scalable platform that enables simultaneous control of multiple environmental factors including temperature, mechanical stress, and food availability. This brief quiescent state, which we refer to as microfluidic-induced sleep, occurs spontaneously in microfluidic chambers, which allows us to track animal movement and perform whole-brain imaging. With these capabilities, we establish that microfluidic-induced sleep meets the behavioral requirements of C. elegans sleep and depends on multiple factors, such as satiety and temperature. Additionally, we show that C. elegans sleep can be induced through mechanosensory pathways. Together, these results establish a model system for studying how animals process multiple sensory pathways to regulate behavioral states.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.