Evidence map›Paper›PMID 31694917›Full record

ArticleThe Journal of biological chemistry2019

The human milk protein-lipid complex HAMLET disrupts glycolysis and induces death in

Hazeline Roche-Hakansson, Goutham Vansarla, Laura R Marks, Anders P Hakansson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Linolenic acid-metronidazole inhibits the growth ofWorld journal of gastroenterology · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Hazeline Roche-HakanssonDepartment of Microbiology and Immunology, University at Buffalo, State University of New York, Buffalo, New York 14203.
Goutham VansarlaDivision of Experimental Infection Medicine, Department of Translational Medicine, Lund University, SE-21428 Malmö, Sweden.ORCID 0000-0002-8622-355X
Laura R MarksDepartment of Medicine, Barnes-Jewish Hospital, Washington University, St. Louis, Missouri 63110.
Anders P HakanssonDivision of Experimental Infection Medicine, Department of Translational Medicine, Lund University, SE-21428 Malmö, Sweden anders_p.hakansson@med.lu.se.ORCID 0000-0002-2834-6009
Lund University · SEBarnes-Jewish Hospital · USUniversity at Buffalo, State University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HAMLET is a complex of human α-lactalbumin (ALA) and oleic acid and kills several Gram-positive bacteria by a mechanism that bears resemblance to apoptosis in eukaryotic cells. To identify HAMLET's bacterial targets, here we used

Indexed as

Adenosine TriphosphateDeoxyglucoseFructose-Bisphosphate AldolaseGlucoseGlyceraldehyde 3-Phosphate Dehydrogenase (NADP+)GlycolysisHumansLactalbuminLipidsMicrobial ViabilityMilk, HumanMilk ProteinsOleic AcidOleic AcidsProteomicsRecombinant ProteinsAdenosine TriphosphateDeoxyglucoseFructose-Bisphosphate AldolaseGlucoseGlyceraldehyde 3-Phosphate Dehydrogenase (NADP+)HAMLET complex, humanLactalbuminLipidsMilk ProteinsOleic AcidOleic AcidsRecombinant Proteinsalpha-lactalbuminantibioticscell deathenergy metabolismenzyme inactivationglycolysisHAMLET (human alpha-lactalbumin made lethal to tumor cells)human milklactic acidmembrane functionmetabolismoleic acidStreptococcusStreptococcus pneumoniae

Identifiers

PMID31694917
PMCPMC6926454
OpenAlexW2983566276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.