Evidence map›Paper›PMID 31694859›Full record

ArticleDiabetes care2020

Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood.

Cole D Bendor, Aya Bardugo, Inbar Zucker, Tali Cukierman-Yaffe, Miri Lutski, Estela Derazne, Tammy Shohat, Ofri Mosenzon, Dorit Tzur, Ari Sapir and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Risk Factors and Mechanisms for Diabetes in Pancreatitis.Gastroenterology clinics of North America · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Acute pancreatitis-induced islet dysfunction in ferrets.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2021
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Cole D BendorDepartment of Military Medicine, Hebrew University, Jerusalem, Israel.
Aya BardugoDepartment of Military Medicine, Hebrew University, Jerusalem, Israel.
Inbar ZuckerSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Tali Cukierman-YaffeSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0003-1289-5633
Miri LutskiMinistry of Health, Israel Center for Disease Control, Ramat Gan, Israel.
Estela DerazneSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Tammy ShohatSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Ofri MosenzonThe Diabetes Unit, Division of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel.
Dorit TzurDepartment of Military Medicine, Hebrew University, Jerusalem, Israel.
Ari SapirDepartment of Military Medicine, Hebrew University, Jerusalem, Israel.
Orit Pinhas-HamielSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Richard G KibbeyDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT.
Itamar RazThe Diabetes Unit, Division of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel.ORCID 0000-0003-0209-4453
Arnon AfekSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Hertzel C GersteinDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-8072-2836
Amir TiroshSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Gilad TwigDepartment of Military Medicine, Hebrew University, Jerusalem, Israel gilad.twig@gmail.com.ORCID 0000-0003-2829-3645
Tel Aviv University · ILHebrew University of Jerusalem · ILIsrael Ministry of Health · ILMcMaster University · CAYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0M
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS P30 DK045735
6 · The paper itself

Abstract

objectiveThe relationship between acute pancreatitis and incident diabetes is unclear. We assessed whether a resolved single event of acute pancreatitis in childhood was associated with incident diabetes in adulthood. RESEARCH DESIGN AND

methodsA nationwide, population-based study of 1,802,110 Israeli adolescents (mean age 17.4 years [range 16-20]) who were examined before compulsory military service between 1979 and 2008 and whose data were linked to the Israeli National Diabetes Registry (INDR). Resolved pancreatitis was defined as a history of a single event of acute pancreatitis with normal pancreatic function at enrollment. Logistic regression analysis was applied.

resultsIncident diabetes developed in 4.6% of subjects with resolved pancreatitis (13 of 281; none of these cases were identified as type 1 diabetes) and 2.5% among the unexposed group (44,463 of 1,801,716). Resolved acute pancreatitis was associated with incident diabetes with an odds ratio (OR) of 2.23 (95% CI 1.25-3.98) with adjustment for age, sex, and birth year. Findings persisted after further adjustments for baseline BMI and sociodemographic confounders (OR 2.10 [95% CI 1.15-3.84]). Childhood pancreatitis was associated with a diagnosis of diabetes at a younger age, with 92% of diabetes case subjects diagnosed before 40 years of age compared with 47% in the unexposed group (

conclusionsA history of acute pancreatitis in childhood with normal pancreatic function in late adolescence is a risk factor for incident type 2 diabetes, especially at young adulthood.

Indexed as

Acute DiseaseAdolescentAdultAge of OnsetChildDiabetes Mellitus, Type 2FemaleHumansIncidenceIsraelMalePancreatitisRegistriesRisk FactorsYoung Adult

Identifiers

PMID31694859
PMCPMC7011197
OpenAlexW2988552088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.