Evidence map›Paper›PMID 31694693›Full record

ArticleSkeletal muscle2019

Barium chloride injures myofibers through calcium-induced proteolysis with fragmentation of motor nerves and microvessels.

Aaron B Morton, Charles E Norton, Nicole L Jacobsen, Charmain A Fernando, D D W Cornelison, Steven S Segal

Open access · goldAbstract read
In one paragraph

Article in Skeletal muscle, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 88 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Decoding Barberry Root's Therapeutic Network: A Synergistic Solution for IBS-D.Combinatorial chemistry & high throughput screening · 2026
    Article
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  13. Article
  14. Chestnut (Nutrients · 2025
    Article
  15. Article
  16. Article
  17. Traumatic Skeletal Muscle Injury and Recovery.Advances in experimental medicine and biology · 2025
    Review
  18. Article
  19. Article
  20. Prenatal and progressive coenzyme QJournal of cachexia, sarcopenia and muscle · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Aaron B MortonDepartment of Medical Pharmacology and Physiology, University of Missouri, MA415 Medical Sciences Building, 1 Hospital Drive, Columbia, MO, 65212, USA.
Charles E NortonDepartment of Medical Pharmacology and Physiology, University of Missouri, MA415 Medical Sciences Building, 1 Hospital Drive, Columbia, MO, 65212, USA.
Nicole L JacobsenDepartment of Medical Pharmacology and Physiology, University of Missouri, MA415 Medical Sciences Building, 1 Hospital Drive, Columbia, MO, 65212, USA.
Charmain A FernandoDepartment of Medical Pharmacology and Physiology, University of Missouri, MA415 Medical Sciences Building, 1 Hospital Drive, Columbia, MO, 65212, USA.
D D W CornelisonDivision of Biological Sciences and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, 65201, USA.
Steven S SegalDepartment of Medical Pharmacology and Physiology, University of Missouri, MA415 Medical Sciences Building, 1 Hospital Drive, Columbia, MO, 65212, USA. segalss@health.missouri.edu.ORCID 0000-0001-5667-2154
University of Missouri Hospital · USUniversity of Missouri · US

Funding

Intercellular Coordination of Blood Flow ControlR37HL041026 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SEGAL, STEVEN S · 2008 to 2018
$3.7M
Ephrin-A3 Specifies Slow Muscle Fiber TypeR01AR067450 · NIAMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI CORNELISON, DAWN D · 2014 to 2020
$1.9M
NHLBI NIH HHS R37 HL041026NIAMS NIH HHS R01 AR067450NIH HHS R37HL041026
6 · The paper itself

Abstract

backgroundLocal injection of BaCl

methodsThe intact extensor digitorum longus (EDL) muscle was isolated from male mice (aged 3-4 months) and irrigated with physiological salt solution (PSS) at 37 °C. Myofiber membrane potential (V

resultsAddition of 1.2% BaCl

conclusionsBaCl

Indexed as

AnimalsBarium CompoundsCalciumChloridesDisease Models, AnimalIn Vitro TechniquesMaleMembrane PotentialsMiceMice, Inbred C57BLMice, TransgenicMicrovesselsMotor NeuronsMuscle Fibers, SkeletalMuscle ProteinsMuscle, Skeletalbarium chlorideBarium CompoundsCalciumChloridesMuscle ProteinsCapillary supplyMotor innervationNeuromuscular junctionSkeletal muscle

Identifiers

PMID31694693
PMCPMC6833148
OpenAlexW2988348870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.