ArticleGenome biology2019
DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits.
Article in Genome biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.Genome biology · 2022Pooled it
- Integrating bulk and single-cell RNA sequencing with GWAS reveals regulatory networks underpinning complex traits in beef cattle.Journal of animal science and biotechnology · 2026Article
- Integrating Proteomics and GWAS to Identify Key Tissues and Genes Underlying Human Complex Diseases.Biology · 2025Article
- Application of GWAS summary data and drug-induced gene expression profiles of neural progenitor cells in psychiatric drug prioritization analysis.Molecular psychiatry · 2025Article
- Genome-wide association study of chlamydia reinfection in African American women.Frontiers in immunology · 2025Article
- Shared genetic aetiology of respiratory diseases: a genome-wide multitraits association analysis.BMJ open respiratory research · 2024Article
- Dissecting the high-resolution genetic architecture of complex phenotypes by accurately estimating gene-based conditional heritability.American journal of human genetics · 2023Article
- Multi-Cell-Type Openness-Weighted Association Studies for Trait-Associated Genomic Segments Prioritization.Genes · 2022Article
- Powerful and robust inference of complex phenotypes' causal genes with dependent expression quantitative loci by a median-based Mendelian randomization.American journal of human genetics · 2022Article
- Article
- Deviation from baseline mutation burden provides powerful and robust rare-variants association test for complex diseases.Nucleic acids research · 2022Article
- Functional annotation of breast cancer risk loci: current progress and future directions.British journal of cancer · 2022Review
- Integrative enrichment analysis of gene expression based on an artificial neuron.BMC medical genomics · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The driver tissues or cell types in which susceptibility genes initiate diseases remain elusive. We develop a unified framework to detect the causal tissues of complex diseases or traits according to selective expression of disease-associated genes in genome-wide association studies (GWASs). This framework consists of three components which run iteratively to produce a converged prioritization list of driver tissues. Additionally, this framework also outputs a list of prioritized genes as a byproduct. We apply the framework to six representative complex diseases or traits with GWAS summary statistics, which leads to the estimation of the lung as an associated tissue of rheumatoid arthritis.
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