ArticleBMC medical genetics2019
Association of high sensitive C-reactive protein with coronary heart disease: a Mendelian randomization study.
Article in BMC medical genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- C-reactive protein (CRP) as a prognostic biomarker in patients with urothelial carcinoma: A systematic review and meta-analysis.Critical reviews in oncology/hematology · 2024Pooled it
- C-reactive protein and coronary atheroma regression following statin therapy: A meta-regression of randomized controlled trials.Frontiers in cardiovascular medicine · 2022Pooled it
- Association between weight-adjusted waist index and C-reactive protein in adults: A population-based study.Medicine · 2026Article
- Systemic Inflammation and Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease and Chronic Kidney Disease.JACC. Advances · 2026Article
- Construction of an explainable machine learning model based on SHAP for predicting cardiovascular mortality risk among American cancer survivors.Discover oncology · 2026Article
- Protective role of the C-reactive protein-albumin-lymphocyte (CALLY) index for cardiovascular risk and mortality.Scientific reports · 2025Article
- The Systemic Link Between Oral Health and Cardiovascular Disease: Contemporary Evidence, Mechanisms, and Risk Factor Implications.Diseases (Basel, Switzerland) · 2025Review
- Validity of high-sensitivity C-reactive protein versus DAD equation for cardiovascular risk assessment in people living with HIV in Nigeria.BMC infectious diseases · 2025Article
- Review
- Association between inflammatory score, healthy lifestyle, and cardiovascular disease: a national cohort study.Frontiers in nutrition · 2025Article
- Association between Inflammatory Burden Index and cardiovascular disease in adult Americans: Evidence from NHANES 2005-2010.Heliyon · 2024Article
- The variations in health cost based on the traditional obesity parameters among patients with coronary artery diseases undergoing cardiac catheterization.BMC health services research · 2024Article
- Exploring the predictive values of CRP and lymphocytes in coronary artery disease based on a machine learning and Mendelian randomization.Frontiers in cardiovascular medicine · 2024Article
- C-Reactive Protein Levels and Risk of Cardiovascular Diseases: A Two-Sample Bidirectional Mendelian Randomization Study.International journal of molecular sciences · 2023Article
- Acute coronary syndrome in antineutrophil cytoplasmic antibody-associated vasculitis: a Korean single-centre cohort study.Journal of rheumatic diseases · 2023Article
- Long-term Trajectories of C-Reactive Protein Among Men Living With and Without HIV Infection in the Multicenter AIDS Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- The role of inflammation and the possibilities of inflammation reduction to prevent cardiovascular events.European heart journal open · 2022Review
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWhether high sensitivity C-reactive protein (hs-CRP) has a causal effect on coronary heart disease (CHD) is unclear. This study investigated the causal effect of hs-CRP on CHD risk using Mendelian Randomization (MR) analysis.
methodsA total of 3802 subjects were recruited in the follow-up study. Linear regression model was used to evaluate the relationship between CRP polymorphisms and hs-CRP. Survival receiver operator characteristic curve method was used to explore the cut-off of hs-CRP on CHD incidence. Cox regression model was applied to detect the association of hs-CRP with CHD by calculating the hazard ratio (HR) and 95% confidence interval (CI). Rs1205 and rs876537 in CRP were selected as instrumental variables in MR analysis.
resultsDuring a median follow-up time of 5.01 years, 98 CHD incidence was identified (47.03/10
conclusionsThe association between hs-CRP and CHD is unlikely to be causal, hs-CRP might be a predictor for incidence of CHD in general population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.