Evidence map›Paper›PMID 31694558›Full record

ArticleBMC infectious diseases2019

Impact of metformin use among tuberculosis close contacts with diabetes mellitus in a nationwide cohort study.

Ming-Chia Lee, Chih-Hsin Lee, Meng-Rui Lee, Jann-Yuan Wang, Shih-Ming Chen

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Ming-Chia LeeDepartment of Pharmacy, New Taipei City Hospital, #3, Sec. 1, New Taipei Blvd., Sanchong Dist, New Taipei City, 24141, Taiwan.
Chih-Hsin LeeDivision of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, #111, Sec. 3, Xinglong Rd., Wenshan Dist, Taipei, 11696, Taiwan.
Meng-Rui LeeDepartment of Internal Medicine, National Taiwan University Hospital, Hsin-Chu, Branch, #25,Lane 442,Sec.1,Jingguo Rd., Hsin-chu, 300, Taiwan.
Jann-Yuan WangDepartment of Internal Medicine, National Taiwan University Hospital, #7, Chung-Shan South Road, Taipei, 10002, Taiwan. jywang@ntu.edu.tw.ORCID http://orcid.org/0000-0003-3406-366X
Shih-Ming ChenSchool of Pharmacy, College of Pharmacy, Taipei Medical University, #250, Wuxing St, Taipei, 11031, Taiwan. smchen@tmu.edu.tw.
Taipei City Hospital · TWNational Taiwan University Hospital · TWTaipei Medical University · TWWan Fang Hospital · TW

Funding

Ministry of Science and Technology, Taiwan (TW) MOST104-2321-B-002-058the Ministry of Health and Welfare MOHW105-CDC-C-114-00103the Ministry of Health and Welfare MOHW106-CDC-C-11400104
6 · The paper itself

Abstract

backgroundThe protective effect of metformin against active tuberculosis (TB) among TB close contacts is unknown.

methodsTB close contacts with diabetes mellitus (DM) and normal renal function were selected from the National Health Insurance Research Database of Taiwan. Metformin users were patients who received ≥90 cumulative defined daily doses within 1 year before the index date. For each metformin user, a propensity-score matched metformin nonuser and an age- and sex-matched healthy TB close contact were selected. The outcome was incident TB, identified using previously validated diagnostic criteria. Independent predictors were investigated using stratified Cox regression analysis. Interaction analysis was also performed.

resultsA total of 5846 TB close contacts who were metformin users, metformin non-users, and healthy contacts were analysed. The incidence of active TB was 755 (600-938), 1117 (927-1335), and 526 (393-689) cases per 100,000 person-years in each group, respectively. Multivariate analysis revealed that healthy contacts had the lowest risk of developing active TB (adjusted hazard ratio [aHR]: 0.42 [0.30-0.60]) and metformin use partially reversed the risk associated with DM (aHR: 0.73 [0.54-0.98]). Subpopulation analysis revealed a significant interaction between insulin use and metformin use.

conclusionsMetformin use is associated with a lower risk of developing active TB among TB close contacts with DM, especially for insulin users. It may be an alternative choice for primary prevention against active TB if no contraindications exist. However, prospective studies are needed to confirm the findings.

Indexed as

AdultAgedComorbidityDatabases, FactualDiabetes MellitusFemaleFollow-Up StudiesHumansHypoglycemic AgentsIncidenceMaleMetforminMiddle AgedMycobacterium tuberculosisPropensity ScoreProportional Hazards ModelsHypoglycemic AgentsMetforminClose contactDiabetes mellitusHost-directed therapyMetforminTuberculosis

Identifiers

PMID31694558
PMCPMC6836500
OpenAlexW2988790608

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.