ArticleBMC microbiology2019
Phenotypic and genotypic characterization of clinical Staphylococcus aureus isolates from Kenya.
Article in BMC microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Distinct genetic programs drive antibiotic resistance and intracellular invasion in emerging MRSA strains.mSystems · 2026Article
- Displacement of Hospital-Acquired, Methicillin-ResistantMicroorganisms · 2024Article
- Staphylococcus aureus associated with surgical site infections in Western Kenya reveals genomic hotspots for pathogen evolution.Access microbiology · 2024Article
- Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance ofmSystems · 2023Article
- Enhancing capacity for national genomics surveillance of antimicrobial resistance in public health laboratories in Kenya.Microbial genomics · 2023Article
- Clonal diversity of Staphylococcus aureus isolates in clinical specimens from selected health facilities in Ethiopia.BMC infectious diseases · 2023Article
- Prevalence and Potential Risk Factors for the Acquisition of Antibiotic-ResistantBioMed research international · 2023Article
- Antimicrobial resistance and clonality ofFrontiers in microbiology · 2023Article
- Characteristics ofPathogens (Basel, Switzerland) · 2022Article
- Multi-Drug ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Molecular Characteristics and Antibiotic Resistance ofPathogens (Basel, Switzerland) · 2022Article
- Genomic Analysis and Antimicrobial Components of M7, anJournal of fungi (Basel, Switzerland) · 2022Article
- Genomic characterization of two community-acquired methicillin-resistantFrontiers in medicine · 2022Article
- Comparative genomics of dairy-associatedFrontiers in microbiology · 2022Article
- A 6-Year Update on the Diversity of Methicillin-ResistantFrontiers in microbiology · 2022Review
- Antibiotic resistance profiles and population structure of disease-associatedMicrobiology (Reading, England) · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe increase and spread of virulent-outbreak associated, methicillin and vancomycin resistant (MRSA/VRSA) Staphylococcus aureus require a better understanding of the resistance and virulence patterns of circulating and emerging strains globally. This study sought to establish the resistance phenotype, and strains of 32 non-duplicate clinical MRSA and MSSA S. aureus isolates from four Kenyan hospitals, identify their resistance and virulence genes and determine the genetic relationships of MRSA with global strains.
methodsAntimicrobial susceptibility profiles were determined on a Vitek 2, genomic DNA sequenced on an Illumina Miseq and isolates typed in-silico. Resistance and virulence genes were identified using ARIBA and phylogenies generated using RAxML.
resultsThe MRSA isolates were 100% susceptible to vancomycin, teicoplanin, linezolid, and tigecycline. Nine distinct CC, 12 ST and 15 spa types including the novel t17826 and STs (4705, 4707) were identified with CC8 and CC152 predominating. MRSA isolates distributed across 3 CCs; CC5-ST39 (1), CC8 - ST241 (4), a novel CC8-ST4705 (1), ST8 (1) and CC152 (1). There was > 90% phenotype-genotype concordance with key resistance genes identified only among MRSA isolates: gyrA, rpoB, and parC mutations, mecA, ant (4')-lb, aph (3')-IIIa, ermA, sat-4, fusA, mphC and msrA. Kenyan MRSA isolates were genetically diverse and most closely related to Tanzanian and UK isolates. There was a significant correlation between map, hlgA, selk, selq and cap8d virulence genes and severe infections.
conclusionThe findings showed a heterogeneous S. aureus population with novel strain types. Though limited by the low number of isolates, this study begins to fill gaps and expand our knowledge of S. aureus epidemiology while uncovering interesting patterns of distribution of strain types which should be further explored. Although last-line treatments are still effective, the potential for outbreaks of both virulent and resistant strains remain, requiring sustained surveillance of S. aureus populations.
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